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Protein Ontology report - interleukin-17A
PR:000001138 - http://purl.obolibrary.org/obo/PR_000001138
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001138   
  PRO nameinterleukin-17A 
  Synonyms
PRO-Short-label: EXACT:IL17A
Gene-based: RELATED:CTLA8 | IL17
Other: EXACT:CTLA-8 | cytotoxic T-lymphocyte-associated antigen 8 | IL-17A
RELATED:IL-17
  Definition"An interleukin-17 that is a translation product of the human IL17A gene or a 1:1 ortholog thereof. The active product is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases." [PRO:CNA, Wikipedia:IL17A] 
  PRO Categorygene 
  ParentPR:000001092 interleukin-17
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF501045
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001138 interleukin-17A, IL17A

organism-gene


PR:Q16552 interleukin-17A (human), hIL17A

organism-modification


PR:000036602 interleukin-17A, signal peptide removed form (human), hIL17A/SigPep-
Yes
Yes
organism-gene


PR:Q5TKT0 interleukin 17_5 (zebrafish), z-IL17A

organism-gene


PR:Q61453 interleukin-17A (rat), rIL17A

organism-gene


PR:Q62386 interleukin-17A (mouse), mIL17A

modification


PR:000018349 interleukin-17A, signal peptide removed form, IL17A/SigPep-

organism-modification


PR:000036602 interleukin-17A, signal peptide removed form (human), hIL17A/SigPep-
Yes
Yes
modification


PR:000025428 interleukin-17A proteolytic cleavage product, IL17A/ClvPrd

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IL17A forms found in complexes   

IL17A Component
 Complexes
PR:000036602 hIL17A/SigPep- PR:000044528 interleukin 17F/17A heterodimer (human)
PR:000044530 interleukin 17A homodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036602 hIL17A/SigPep-
UniProtKB:Q16552, 24-155 | PRO_0000015423
"An interleukin-17A, signal peptide removed form in human. UniProtKB:Q16552, 24-155." [PMID:15055556, PMID:15340161, PMID:7499828, PRO:CNA]		 enablesGO:0005125 cytokine activity PMID:7499828
GO:0042803 protein homodimerization activity PMID:15055556
located_inGO:0005615 extracellular space PMID:15340161; PMID:7499828