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Protein Ontology report - NF-kappa-B essential modulator
PR:000001752 - http://purl.obolibrary.org/obo/PR_000001752
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000001752   
  PRO nameNF-kappa-B essential modulator 
  Synonyms
PRO-Short-label: EXACT:IKBKG
Gene-based: RELATED:FIP3 | NEMO
Other: EXACT:FIP-3 | I-kappa-B kinase subunit gamma | IkB kinase subunit gamma | IkB kinase-associated protein 1 | IKK-gamma | IKKAP1 | IKKG | inhibitor of nuclear factor kappa-B kinase subunit gamma | NF-kappa-B essential modifier
  Definition"A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160
  PRO Categorygene 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038160
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001752 NF-kappa-B essential modulator, IKBKG


organism-gene



PR:O88522 NF-kappa-B essential modulator (mouse), mIKBKG


Yes
organism-gene



PR:Q6TMG5 NF-kappa-B essential modulator (rat), rIKBKG


organism-gene



PR:Q9Y6K9 NF-kappa-B essential modulator (human), hIKBKG


Yes
organism-sequence



PR:000060620 NF-kappa-B essential modulator sequence variant C417R (human), hIKBKG/var:C417R


organism-sequence



PR:000061455 NF-kappa-B essential modulator sequence variant R175P (human), hIKBKG/var:R175P


organism-sequence



PR:000062347 NF-kappa-B essential modulator sequence variant R173G (human), hIKBKG/var:R173G


organism-sequence



PR:000062826 NF-kappa-B essential modulator sequence variant D406V (human), hIKBKG/var:D406V


organism-sequence



PR:000062944 NF-kappa-B essential modulator sequence variant L153R (human), hIKBKG/var:L153R


organism-sequence



PR:000064418 NF-kappa-B essential modulator sequence variant E391* (human), hIKBKG/var:E391*


organism-sequence



PR:Q9Y6K9-1 NF-kappa-B essential modulator isoform 1 (human), hIKBKG/iso:1


organism-modification



PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human), hIKBKG/iso:1/Phos:1


organism-modification



PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human), hIKBKG/iso:1/Phos:2


organism-modification



PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human), hIKBKG/iso:1/Phos:3


organism-sequence



PR:Q9Y6K9-2 NF-kappa-B essential modulator isoform h2 (human), hIKBKG/iso:h2


organism-sequence



PR:Q9Y6K9-3 NF-kappa-B essential modulator isoform h3 (human), hIKBKG/iso:h3


organism-modification



PR:000047980 NF-kappa-B essential modulator ubiquitinated 1 (human), hIKBKG/Ubiq:1


organism-modification



PR:000064705 NF-kappa-B essential modulator ubiquitinated 2 (human), hIKBKG/Ubiq:2


organism-modification



PR:000064734 NF-kappa-B essential modulator sumoylated 1 (human), hIKBKG/Sumo:1


sequence



PR:000001763 NF-kappa-B essential modulator isoform 1, IKBKG/iso:1


organism-sequence



PR:Q9Y6K9-1 NF-kappa-B essential modulator isoform 1 (human), hIKBKG/iso:1


organism-modification



PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human), hIKBKG/iso:1/Phos:1


organism-modification



PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human), hIKBKG/iso:1/Phos:2


organism-modification



PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human), hIKBKG/iso:1/Phos:3


modification



PR:000001764 NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form, IKBKG/iso:1/PhosUbiq+


modification



PR:000001765 NF-kappa-B essential modulator isoform 1 phosphorylated form, IKBKG/iso:1/PhosRes+


modification



PR:000001764 NF-kappa-B essential modulator isoform 1 phosphorylated and ubiquitinated form, IKBKG/iso:1/PhosUbiq+


modification



PR:000001766 NF-kappa-B essential modulator isoform 1 phosphorylated 1, IKBKG/iso:1/Phos:1


organism-modification



PR:000036612 NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human), hIKBKG/iso:1/Phos:1


modification



PR:000001767 NF-kappa-B essential modulator isoform 1 phosphorylated 2, IKBKG/iso:1/Phos:2


organism-modification



PR:000036613 NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human), hIKBKG/iso:1/Phos:2


modification



PR:000001768 NF-kappa-B essential modulator isoform 1 phosphorylated 3, IKBKG/iso:1/Phos:3


organism-modification



PR:000036614 NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human), hIKBKG/iso:1/Phos:3


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IKBKG forms found in complexes   

IKBKG Component
Complexes
PR:O88522 mIKBKG PR:000036118^P000036119
PR:Q9Y6K9 hIKBKG PR:000026457^P000035833^P000036053^P000037364