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Protein Ontology report - CD14 molecule
PR:000001889 - http://purl.obolibrary.org/obo/PR_000001889
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001889   
  PRO nameCD14 molecule 
  Synonyms
PRO-Short-label: EXACT:CD14
Other: EXACT:monocyte differentiation antigen CD14 | myeloid cell-specific leucine-rich glycoprotein
  Definition"A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  CommentRequested by=CL. 
  PRO Categorygene 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 0                                        
         Modification7                                                  Organism-Modification 19                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002017
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001889 CD14 molecule, CD14

Yes
organism-gene


PR:B0BL87 CD14 molecule (chicken), chick-CD14
Yes
Yes
organism-gene


PR:P08571 monocyte differentiation antigen CD14 (human), hCD14
Yes
organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble
Yes
organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human), hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human), hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000050392 presepsin (human), hPSEP

organism-modification


PR:000054476 monocyte differentiation antigen CD14 N-glycosylated 1 (human), hCD14/NGlyco:1

organism-modification


PR:000054477 monocyte differentiation antigen CD14 O-glycosylated 1 (human), hCD14/OGlyco:1

organism-modification


PR:000054478 monocyte differentiation antigen CD14 O-glycosylated 2 (human), hCD14/OGlyco:2

organism-modification


PR:000054479 monocyte differentiation antigen CD14 O-glycosylated 3 (human), hCD14/OGlyco:3

organism-modification


PR:000054480 monocyte differentiation antigen CD14 O-glycosylated 4 (human), hCD14/OGlyco:4

organism-modification


PR:000054481 monocyte differentiation antigen CD14 O-glycosylated 5 (human), hCD14/OGlyco:5

organism-modification


PR:000065690 monocyte differentiation antigen CD14 cysteinylated 1 (human), hCD14/Cyst:1

organism-modification


PR:000079106 monocyte differentiation antigen CD14 deaminated 1 (human), hCD14/Deam:1

organism-gene


PR:P10810 monocyte differentiation antigen CD14 (mouse), mCD14
Yes
organism-modification


PR:000036850 CD14 molecule cleaved and soluble form (mouse), mCD14/ClvPrd/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble

organism-modification


PR:000036946 CD14 molecule cleaved 2 (mouse), mCD14/Clv:2

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse), mCD14/Clv:2/anchored

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble
Yes
organism-gene


PR:Q63691 monocyte differentiation antigen CD14 (rat), rCD14

modification


PR:000018574 CD14 molecule, signal peptide removed form, CD14/SigPep-

modification


PR:000002146 CD14 molecule cleaved 1 soluble form, CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble
Yes
modification


PR:000002148 CD14 molecule cleaved and GPI-anchored form, CD14/ClvPrd/anchored

modification


PR:000036848 CD14 molecule cleaved 2, CD14/Clv:2
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form, CD14/Clv:2/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000002149 CD14 molecule cleaved 2 GPI-anchored form, CD14/Clv:2/anchored

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse), mCD14/Clv:2/anchored

Yes
organism-modification


PR:000036946 CD14 molecule cleaved 2 (mouse), mCD14/Clv:2

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037470 CD14 molecule cleaved 2 GPI-anchored form (mouse), mCD14/Clv:2/anchored

organism-modification


PR:000037480 CD14 molecule cleaved 2 (human), hCD14/Clv:2

Yes
organism-modification


PR:000035702 CD14 molecule cleaved 2 GPI-anchored form (human), hCD14/Clv:2/anchored
Yes
Yes
organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
modification


PR:000036849 CD14 molecule cleaved and soluble form, CD14/ClvPrd/soluble

Yes
modification


PR:000002146 CD14 molecule cleaved 1 soluble form, CD14/Clv:1/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble
Yes
organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble
Yes
modification


PR:000002147 CD14 molecule cleaved 2 soluble form, CD14/Clv:2/soluble

organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble
Yes
Yes
organism-modification


PR:000036850 CD14 molecule cleaved and soluble form (mouse), mCD14/ClvPrd/soluble

Yes
organism-modification


PR:000029986 CD14 molecule cleaved 2 soluble form (mouse), mCD14/Clv:2/soluble

organism-modification


PR:000037469 CD14 molecule cleaved 1 soluble form (mouse), mCD14/Clv:1/soluble

organism-modification


PR:000036945 CD14 molecule cleaved and soluble form (human), hCD14/ClvPrd/soluble

organism-modification


PR:000035703 CD14 molecule cleaved 2 soluble form (human), hCD14/Clv:2/soluble

organism-modification


PR:000036615 CD14 molecule cleaved 1 soluble form (human), hCD14/Clv:1/soluble

organism-modification


PR:000050392 presepsin (human), hPSEP

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CD14 forms found in complexes   

CD14 Component
 Complexes
PR:000001889 CD14 PR:000037465
PR:000002147 CD14/Clv:2/soluble PR:000025494^P000025496^P000025498
PR:000002149 CD14/Clv:2/anchored PR:000025493^P000025495^P000025497
PR:000035702 hCD14/Clv:2/anchored PR:000025773^P000027208^P000028680^P000036022^P000036053^P000037464
PR:000035703 hCD14/Clv:2/soluble PR:000037463^P000037479
PR:000036849 CD14/ClvPrd/soluble PR:000029989
PR:000036850 mCD14/ClvPrd/soluble PR:000037467
PR:000037470 mCD14/Clv:2/anchored PR:000037468^P000037476
PR:000037480 hCD14/Clv:2 PR:000036135^P000037446^P000037447^P000037448
PR:B0BL87 chick-CD14 PR:000037466
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702
hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167 | GPI-anchored form of CD14 (human) | GPI-N345-CD14 (human) | PRO_0000020885, Asn-345, MOD:00167		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703
hCD14/Clv:2/soluble
Secreted form of CD14 (human)		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615
hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367 | PRO_0000020884		 located_inGO:0005576 extracellular region PMID:7519994
PR:000036848
CD14/Clv:2
 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI:3836081; PMID:18854309
GO:0016020 membrane MGI:3836081; PMID:18854309
PR:000037469
mCD14/Clv:1/soluble
UniProtKB:P10810, 16-358 | Secreted CD14 (mouse)		 located_inCL:0000129 microglial cell PMID:24659539
PR:B0BL87
chick-CD14
 located_inGO:0005886 plasma membrane PMID:18761368
GO:0009986 cell surface PMID:18761368
PR:P08571
hCD14
CD14 | myeloid cell-specific leucine-rich glycoprotein (human)		 located_inNOT CL:0000127 astrocyte PMID:24659539
PR:P10810
mCD14
Cd14 | CD14 (mouse) | myeloid cell-specific leucine-rich glycoprotein (mouse)		 located_inCL:0000127 astrocyte PMID:24659539