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Protein Ontology report - RAC-alpha serine/threonine-protein kinase
PR:000002190 - http://purl.obolibrary.org/obo/PR_000002190
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002190   
  PRO nameRAC-alpha serine/threonine-protein kinase 
  Synonyms
PRO-Short-label: EXACT:AKT1
Gene-based: RELATED:Akt | RAC
PKB (BROAD)
Other: EXACT:AKT1 kinase | PKB alpha | protein kinase B | protein kinase B alpha | proto-oncogene c-Akt | RAC-PK-alpha | thymoma viral proto-oncogene
  Definition"An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000029189 AKT kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification5                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1479
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002190 RAC-alpha serine/threonine-protein kinase, AKT1

organism-gene


PR:P31749 RAC-alpha serine/threonine-protein kinase (human), hAKT1

organism-sequence


PR:000061890 RAC-alpha serine/threonine-protein kinase sequence variant E17K (human), hAKT1/var:E17K

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human), hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human), hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31749-2 RAC-alpha serine/threonine-protein kinase isoform h2 (human), hAKT1/iso:h2

organism-modification


PR:000046294 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human), hAKT1/Phos:3

organism-modification


PR:000046295 RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human), hAKT1/Phos:4

organism-modification


PR:000046296 RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human), hAKT1/Phos:1

organism-modification


PR:000046297 RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human), hAKT1/Phos:5

organism-modification


PR:000061529 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 1 (human), hAKT1/var:E17K/Phos:1

organism-modification


PR:000061599 RAC-alpha serine/threonine-protein kinase sequence variant E17K phosphorylated 2 (human), hAKT1/var:E17K/Phos:2

organism-modification


PR:000065619 RAC-alpha serine/threonine-protein kinase methylated 1 (human), hAKT1/Me:1

organism-modification


PR:000068716 RAC-alpha serine/threonine-protein kinase phosphorylated 2 (human), hAKT1/Phos:2

organism-modification


PR:000072278 RAC-alpha serine/threonine-protein kinase deaminated 1 (human), hAKT1/Deam:1

organism-gene


PR:P31750 RAC-alpha serine/threonine-protein kinase (mouse), mAKT1

organism-sequence


PR:P31750-1 RAC-alpha serine/threonine-protein kinase isoform 1 (mouse), mAKT1/iso:1

organism-modification


PR:000049940 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse), mAKT1/Phos:3

organism-modification


PR:000049942 RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse), mAKT1/UnPhos:3

organism-modification


PR:000050596 RAC-alpha serine/threonine-protein kinase phosphorylated 1 (mouse), mAKT1/Phos:1

organism-gene


PR:P47196 RAC-alpha serine/threonine-protein kinase (rat), rAKT1

sequence


PR:000002286 RAC-alpha serine/threonine-protein kinase isoform 1, AKT1/iso:1

organism-sequence


PR:P31749-1 RAC-alpha serine/threonine-protein kinase isoform 1 (human), hAKT1/iso:1

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hAKT1/iso:1/Phos:2
Yes
organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human), hAKT1/iso:1/Phos:1
Yes
organism-sequence


PR:P31750-1 RAC-alpha serine/threonine-protein kinase isoform 1 (mouse), mAKT1/iso:1

modification


PR:000003102 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form, AKT1/iso:1/PhosRes+

modification


PR:000003103 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1, AKT1/iso:1/Phos:1

organism-modification


PR:000028994 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human), hAKT1/iso:1/Phos:1
Yes
modification


PR:000027472 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2, AKT1/iso:1/Phos:2

organism-modification


PR:000027473 RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human), hAKT1/iso:1/Phos:2
Yes
modification


PR:000049939 RAC-alpha serine/threonine-protein kinase phosphorylated 3, AKT1/Phos:3

organism-modification


PR:000046294 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human), hAKT1/Phos:3

organism-modification


PR:000049940 RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse), mAKT1/Phos:3

modification


PR:000049941 RAC-alpha serine/threonine-protein kinase unphosphorylated 3, AKT1/UnPhos:3

organism-modification


PR:000049942 RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse), mAKT1/UnPhos:3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027473 hAKT1/iso:1/Phos:2
UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:16549426
PR:000028994 hAKT1/iso:1/Phos:1
UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046 | Akt1 active form (human)
"A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]		 acts_upstream_of_or_withinGO:0032869 cellular response to insulin stimulus PMID:8978681
GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
enablesGO:0004672 protein kinase activity PMID:8978681
GO:0004674 protein serine/threonine kinase activity PMID:12138205
GO:0005515 protein binding PMID:12138205
GO:0005515 protein binding PMID:12138205