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Protein Ontology report - TNF receptor-associated factor
PR:000002191 - http://purl.obolibrary.org/obo/PR_000002191
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002191   
  PRO nameTNF receptor-associated factor 
  Synonyms
Other: EXACT:TRAF
  Definition"A protein that is a translation product of a family of genes including the six human genes, TRAF1 to TRAF6. The core architectures of this protein consists of a zinc finger C3HC4 type (Ring finger) (Pfam:PF00097), a TRAF-type zinc finger (Pfam:PF02176) and a MATH domain (Pfam:PF00917)." [PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 16                                        
         Sequence10                                                  Organism-Sequence 22                                        
         Modification6                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF015614
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000002191 TNF receptor-associated factor, AKT1

gene


PR:000002287 TNF receptor-associated factor 1, TRAF1

organism-gene


PR:P39428 TNF receptor-associated factor 1 (mouse), mTRAF1

organism-sequence


PR:P39428-1 TNF receptor-associated factor 1 isoform 1 (mouse), mTRAF1/iso:1

organism-gene


PR:Q13077 TNF receptor-associated factor 1 (human), hTRAF1

organism-sequence


PR:Q13077-1 TNF receptor-associated factor 1 isoform 1 (human), hTRAF1/iso:1

organism-sequence


PR:Q13077-2 TNF receptor-associated factor 1 isoform h2 (human), hTRAF1/iso:h2

organism-modification


PR:000066472 TNF receptor-associated factor 1 methylated 1 (human), hTRAF1/Me:1

organism-modification


PR:000070945 TNF receptor-associated factor 1 methylated 2 (human), hTRAF1/Me:2

organism-modification


PR:000071340 TNF receptor-associated factor 1 methylated 3 (human), hTRAF1/Me:3

organism-modification


PR:000075922 TNF receptor-associated factor 1 cysteinylated 1 (human), hTRAF1/Cyst:1

organism-modification


PR:000079290 TNF receptor-associated factor 1 cysteinylated 2 (human), hTRAF1/Cyst:2

organism-modification


PR:000080281 TNF receptor-associated factor 1 phosphorylated 1 (human), hTRAF1/Phos:1

organism-modification


PR:000081420 TNF receptor-associated factor 1 methylated 4 (human), hTRAF1/Me:4

organism-modification


PR:000081789 TNF receptor-associated factor 1 methylated 5 (human), hTRAF1/Me:5

sequence


PR:000002373 TNF receptor-associated factor 1 isoform 1, TRAF1/iso:1

organism-sequence


PR:P39428-1 TNF receptor-associated factor 1 isoform 1 (mouse), mTRAF1/iso:1

organism-sequence


PR:Q13077-1 TNF receptor-associated factor 1 isoform 1 (human), hTRAF1/iso:1

gene


PR:000002288 TNF receptor-associated factor 2, TRAF2

organism-gene


PR:P39429 TNF receptor-associated factor 2 (mouse), mTRAF2

organism-sequence


PR:P39429-1 TNF receptor-associated factor 2 isoform 1 (mouse), mTRAF2/iso:1

organism-sequence


PR:P39429-2 TNF receptor-associated factor 2 isoform 2 (mouse), mTRAF2/iso:2

organism-gene


PR:Q12933 TNF receptor-associated factor 2 (human), hTRAF2

organism-sequence


PR:Q12933-1 TNF receptor-associated factor 2 isoform 1 (human), hTRAF2/iso:1

organism-sequence


PR:Q12933-2 TNF receptor-associated factor 2 isoform 2 (human), hTRAF2/iso:2

organism-sequence


PR:Q12933-3 TNF receptor-associated factor 2 isoform h3 (human), hTRAF2/iso:h3

organism-sequence


PR:Q12933-4 TNF receptor-associated factor 2 isoform h4 (human), hTRAF2/iso:h4

organism-modification


PR:000028382 TNF receptor-associated factor 2, initiator methionine removed form (human), hTRAF2/InitMet-

Yes
organism-modification


PR:000049534 TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human), hTRAF2/InitMet-/UbiqLys+

organism-modification


PR:000045896 TNF receptor-associated factor 2 phosphorylated 1 (human), hTRAF2/Phos:1

organism-modification


PR:000069067 TNF receptor-associated factor 2 cysteinylated 1 (human), hTRAF2/Cyst:1

organism-modification


PR:000079608 TNF receptor-associated factor 2 methylated 1 (human), hTRAF2/Me:1

sequence


PR:000002374 TNF receptor-associated factor 2 isoform 1, TRAF2/iso:1

organism-sequence


PR:P39429-1 TNF receptor-associated factor 2 isoform 1 (mouse), mTRAF2/iso:1

organism-sequence


PR:Q12933-1 TNF receptor-associated factor 2 isoform 1 (human), hTRAF2/iso:1

modification


PR:000026641 TNF receptor-associated factor 2 isoform 1, initiator methionine removed form, TRAF2/iso:1/InitMet-

sequence


PR:000002375 TNF receptor-associated factor 2 isoform 2, TRAF2/iso:2

organism-sequence


PR:P39429-2 TNF receptor-associated factor 2 isoform 2 (mouse), mTRAF2/iso:2

sequence


PR:000002376 TNF receptor-associated factor 2 isoform 3, TRAF2/iso:3

organism-sequence


PR:Q12933-2 TNF receptor-associated factor 2 isoform 2 (human), hTRAF2/iso:2

modification


PR:000018757 TNF receptor-associated factor 2, initiator methionine removed form, TRAF2/InitMet-

modification


PR:000026641 TNF receptor-associated factor 2 isoform 1, initiator methionine removed form, TRAF2/iso:1/InitMet-

organism-modification


PR:000028382 TNF receptor-associated factor 2, initiator methionine removed form (human), hTRAF2/InitMet-

Yes
organism-modification


PR:000049534 TNF receptor-associated factor 2, initiator methionine removed ubiquitinated form (human), hTRAF2/InitMet-/UbiqLys+

gene


PR:000002289 TNF receptor-associated factor 3, TRAF3

organism-gene


PR:Q13114 TNF receptor-associated factor 3 (human), hTRAF3

Yes
organism-sequence


PR:Q13114-1 TNF receptor-associated factor 3 isoform 1 (human), hTRAF3/iso:1

organism-sequence


PR:Q13114-2 TNF receptor-associated factor 3 isoform h2 (human), hTRAF3/iso:h2

organism-modification


PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human), hTRAF3/K63polyUbiq+

Yes
organism-modification


PR:000064750 TNF receptor-associated factor 3 ubiquitinated form (human), hTRAF3/UbiqLys+

organism-modification


PR:000069328 TNF receptor-associated factor 3 cysteinylated 1 (human), hTRAF3/Cyst:1

organism-modification


PR:000083316 TNF receptor-associated factor 3 deaminated 1 (human), hTRAF3/Deam:1

organism-gene


PR:Q54FC5 TNF receptor-associated factor family protein DDB_G0290965 (Dictyostelium discoideum), Dicty-TRAF3

organism-gene


PR:Q60803 TNF receptor-associated factor 3 (mouse), mTRAF3

Yes
organism-sequence


PR:Q60803-1 TNF receptor-associated factor 3 isoform 1 (mouse), mTRAF3/iso:1

sequence


PR:000002377 TNF receptor-associated factor 3 isoform 1, TRAF3/iso:1

organism-sequence


PR:Q13114-1 TNF receptor-associated factor 3 isoform 1 (human), hTRAF3/iso:1

organism-sequence


PR:Q60803-1 TNF receptor-associated factor 3 isoform 1 (mouse), mTRAF3/iso:1

modification


PR:000036031 TNF receptor-associated factor 3 K63-polyubiquitinated form, TRAF3/K63polyUbiqLys+

organism-modification


PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human), hTRAF3/K63polyUbiq+

Yes
gene


PR:000002290 TNF receptor-associated factor 4, TRAF4

organism-gene


PR:G5EG80 F45G2.6 (worm), TRAF4 (worm)

organism-gene


PR:Q61382 TNF receptor-associated factor 4 (mouse), mTRAF4

organism-sequence


PR:Q61382-1 TNF receptor-associated factor 4 isoform 1 (mouse), mTRAF4/iso:1

organism-gene


PR:Q9BUZ4 TNF receptor-associated factor 4 (human), hTRAF4

organism-sequence


PR:Q9BUZ4-1 TNF receptor-associated factor 4 isoform 1 (human), hTRAF4/iso:1

organism-sequence


PR:Q9BUZ4-2 TNF receptor-associated factor 4 isoform 2 (human), hTRAF4/iso:2

organism-modification


PR:000046044 TNF receptor-associated factor 4 phosphorylated 1 (human), hTRAF4/Phos:1

organism-modification


PR:000068768 TNF receptor-associated factor 4 cysteinylated 1 (human), hTRAF4/Cyst:1

sequence


PR:000002378 TNF receptor-associated factor 4 isoform 1, TRAF4/iso:1

organism-sequence


PR:Q61382-1 TNF receptor-associated factor 4 isoform 1 (mouse), mTRAF4/iso:1

organism-sequence


PR:Q9BUZ4-1 TNF receptor-associated factor 4 isoform 1 (human), hTRAF4/iso:1

sequence


PR:000002379 TNF receptor-associated factor 4 isoform 2, TRAF4/iso:2

organism-sequence


PR:Q9BUZ4-2 TNF receptor-associated factor 4 isoform 2 (human), hTRAF4/iso:2

gene


PR:000002291 TNF receptor-associated factor 5, TRAF5

organism-gene


PR:O00463 TNF receptor-associated factor 5 (human), hTRAF5

organism-sequence


PR:O00463-1 TNF receptor-associated factor 5 isoform 1 (human), hTRAF5/iso:1

organism-sequence


PR:O00463-2 TNF receptor-associated factor 5 isoform h2 (human), hTRAF5/iso:h2

organism-sequence


PR:O00463-3 TNF receptor-associated factor 5 isoform h3 (human), hTRAF5/iso:h3

organism-modification


PR:000069096 TNF receptor-associated factor 5 phosphorylated 1 (human), hTRAF5/Phos:1

organism-gene


PR:P70191 TNF receptor-associated factor 5 (mouse), mTRAF5

organism-sequence


PR:P70191-1 TNF receptor-associated factor 5 isoform 1 (mouse), mTRAF5/iso:1

sequence


PR:000002380 TNF receptor-associated factor 5 isoform 1, TRAF5/iso:1

organism-sequence


PR:O00463-1 TNF receptor-associated factor 5 isoform 1 (human), hTRAF5/iso:1

organism-sequence


PR:P70191-1 TNF receptor-associated factor 5 isoform 1 (mouse), mTRAF5/iso:1

gene


PR:000002292 TNF receptor-associated factor 6, TRAF6

organism-gene


PR:B5DF45 TNF receptor-associated factor 6 (rat), rTRAF6

organism-gene


PR:P70196 TNF receptor-associated factor 6 (mouse), mTRAF6

Yes
organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse), mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse), mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse), mTRAF6/iso:2

organism-gene


PR:Q6IWL4 TNF receptor-associated factor 6 (zebrafish), z-TRAF6

organism-gene


PR:Q9Y4K3 TNF receptor-associated factor 6 (human), hTRAF6

Yes
organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human), hTRAF6/iso:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human), hTRAF6/K63polyUbiq:1
Yes
Yes
organism-modification


PR:000064696 TNF receptor-associated factor 6 ubiquitinated form (human), hTRAF6/UbiqLys+

organism-modification


PR:000066371 TNF receptor-associated factor 6 cysteinylated 1 (human), hTRAF6/Cyst:1

sequence


PR:000002381 TNF receptor-associated factor 6 isoform 1, TRAF6/iso:1

organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse), mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse), mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human), hTRAF6/iso:1

modification


PR:000003138 TNF receptor-associated factor 6 isoform 1 ubiquitinated form, TRAF6/iso:1/UbiqLys+

modification


PR:000003139 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1, TRAF6/iso:1/K63polyUbiq:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse), mTRAF6/iso:1/K63polyUbiq:1

sequence


PR:000002382 TNF receptor-associated factor 6 isoform 2, TRAF6/iso:2

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse), mTRAF6/iso:2

modification


PR:000035713 TNF receptor-associated factor 6 K63-polyubiquitinated 1, TRAF6/K63polyUbiq:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human), hTRAF6/K63polyUbiq:1
Yes
Yes
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AKT1 forms found in complexes   

AKT1 Component
 Complexes
PR:000028382 hTRAF2/InitMet- PR:000028432^P000028434^P000028435^P000028437
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715^P000035734^P000035738^P000035740^P000037338^P000037340^P000037342
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030^P000036034^P000036036^P000036038^P000036041^P000036123^P000036124^P000037315^P000037320^P000037322^P000037354^P000037356^P000037358^P000037360
PR:P70196 mTRAF6 PR:000035710^P000036101^P000036105^P000036109^P000036111^P000036114^P000036117^P000037471
PR:Q13114 hTRAF3 PR:000036022^P000037310^P000037320^P000037322^P000037354^P000037356^P000037358^P000037360
PR:Q60803 mTRAF3 PR:000028683^P000036090^P000036093^P000036095^P000036097^P000036099^P000037311^P000037313
PR:Q9Y4K3 hTRAF6 PR:000028680^P000037344
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714
hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772 | K63-pUb-TRAF6		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894