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Protein Ontology report - Bcl2-associated agonist of cell death isoform 1
PR:000002280 -
http://purl.obolibrary.org/obo/PR_000002280
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000002280
PRO name
Bcl2-associated agonist of cell death isoform 1
Synonyms
PRO-Short-label
:
EXACT:
BAD/iso:1
Other
:
EXACT:
BAD isoform alpha | bcl-xL/Bcl-2-associated death promoter
Definition
"A Bcl2-associated agonist of cell death that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q61337-1
or a 1:1 ortholog thereof." [PRO:JAN]
PRO Category
sequence
Parent
PR:000002184
Bcl2-associated agonist of cell death
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
10
Organism-Modification
11
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000002280
Bcl2-associated agonist of cell death isoform 1, BAD/iso:1
organism-sequence
PR:O35147-1
Bcl2-associated agonist of cell death isoform Alpha (rat), rBAD/iso:Alpha
Yes
organism-modification
PR:000026134
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat), rBAD/iso:1/Phos:3
Yes
organism-modification
PR:000044748
Bcl2-associated agonist of cell death isoform 1 unmodified form (rat), rBAD/iso:1/UnMod
Yes
organism-sequence
PR:Q61337-1
Bcl2-associated agonist of cell death isoform 1 (mouse), mBAD/iso:1
organism-modification
PR:000026133
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse), mBAD/iso:1/Phos:2
Yes
organism-modification
PR:000026135
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse), mBAD/iso:1/Phos:4
Yes
organism-modification
PR:000026136
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse), mBAD/iso:1/Phos:5
Yes
organism-modification
PR:000026137
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse), mBAD/iso:1/Phos:6
Yes
organism-modification
PR:000026138
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse), mBAD/iso:1/Phos:7
organism-modification
PR:000026139
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse), mBAD/iso:1/Phos:8
Yes
organism-modification
PR:000026167
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse), mBAD/iso:1/Phos:1
Yes
organism-modification
PR:000037809
Bcl2-associated agonist of cell death isoform 1 unphosphorylated 1 (mouse), mBAD/iso:1/UnPhos:1
organism-modification
PR:000044747
Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse), mBAD/iso:1/UnMod
Yes
modification
PR:000002843
Bcl2-associated agonist of cell death isoform 1 unmodified form, BAD/iso:1/UnMod
organism-modification
PR:000044747
Bcl2-associated agonist of cell death isoform 1 unmodified form (mouse), mBAD/iso:1/UnMod
Yes
organism-modification
PR:000044748
Bcl2-associated agonist of cell death isoform 1 unmodified form (rat), rBAD/iso:1/UnMod
Yes
modification
PR:000003084
Bcl2-associated agonist of cell death isoform 1 phosphorylated form, BAD/iso:1/PhosRes+
modification
PR:000003085
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1, BAD/iso:1/Phos:1
organism-modification
PR:000026167
Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 (mouse), mBAD/iso:1/Phos:1
Yes
modification
PR:000003086
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2, BAD/iso:1/Phos:2
organism-modification
PR:000026133
Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 (mouse), mBAD/iso:1/Phos:2
Yes
modification
PR:000003087
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3, BAD/iso:1/Phos:3
organism-modification
PR:000026134
Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 (rat), rBAD/iso:1/Phos:3
Yes
modification
PR:000003233
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4, BAD/iso:1/Phos:4
organism-modification
PR:000026135
Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 (mouse), mBAD/iso:1/Phos:4
Yes
modification
PR:000003238
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5, BAD/iso:1/Phos:5
organism-modification
PR:000026136
Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 (mouse), mBAD/iso:1/Phos:5
Yes
modification
PR:000003269
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6, BAD/iso:1/Phos:6
organism-modification
PR:000026137
Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 (mouse), mBAD/iso:1/Phos:6
Yes
modification
PR:000025849
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7, BAD/iso:1/Phos:7
organism-modification
PR:000026138
Bcl2-associated agonist of cell death isoform 1 phosphorylated 7 (mouse), mBAD/iso:1/Phos:7
modification
PR:000025850
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8, BAD/iso:1/Phos:8
organism-modification
PR:000026139
Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 (mouse), mBAD/iso:1/Phos:8
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026133
mBAD/iso:1/Phos:2
UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 2 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136/Ser-155, MOD:00046." [PMID:10880354, PMID:10949026, PRO:JAN]
acts_upstream_of_or_within
GO:0043066
negative regulation of apoptotic process
PMID:10949026
enables
NOT
GO:0005515
protein binding
with
PR:000003237
fam:14-3-3
PMID:10949026
NOT
GO:0005515
protein binding
with
PR:P63101-1
PMID:10949026
NOT
GO:0005515
protein binding
with
PR:Q64373-1
PMID:10949026
NOT
GO:0005515
protein binding
with
PR:Q07817-1
PMID:10949026
PR:000026134
rBAD/iso:1/Phos:3
UniProtKB:O35147-1, Ser-112, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 3 in rat. UniProtKB:O35147-1, Ser-112, MOD:00046." [PMID:10195903, PMID:10597268, PRO:JAN]
enables
decreased
GO:0005515
protein binding
with
PR:P53563-1
PMID:10195903
GO:0019902
phosphatase binding
PMID:10195903
located_in
GO:0005829
cytosol
PMID:10195903
PR:000026135
mBAD/iso:1/Phos:4
UniProtKB:Q61337-1, Thr-201, MOD:00047
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 4 in mouse. UniProtKB:Q61337-1, Thr-201, MOD:00047." [PMID:14967141, PRO:JAN]
acts_upstream_of_or_within
GO:0043066
negative regulation of apoptotic process
PMID:14967141
enables
decreased
GO:0005515
protein binding
with
PR:Q64373-1
PMID:14967141
PR:000026136
mBAD/iso:1/Phos:5
UniProtKB:Q61337-1, Ser-136, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 5 in mouse. UniProtKB:Q61337-1, Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
enables
GO:0005515
protein binding
with
PR:P63101
KCIP-1 (mouse)
PMID:12049737
PR:000026137
mBAD/iso:1/Phos:6
UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 6 in mouse. UniProtKB:Q61337-1, Ser-128/Ser-136, MOD:00046." [PMID:12049737, PRO:JAN]
acts_upstream_of_or_within
GO:0051402
neuron apoptotic process
PMID:12049737
PR:000026139
mBAD/iso:1/Phos:8
UniProtKB:Q61337-1, Ser-155, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 8 in mouse. UniProtKB:Q61337-1, Ser-155, MOD:00046." [PMID:10880354, PRO:CNA]
enables
GO:0071889
14-3-3 protein binding
with
PR:P61982
mYWHAG
PMID:10880354
PR:000026167
mBAD/iso:1/Phos:1
UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046
"A Bcl2-associated agonist of cell death isoform 1 phosphorylated 1 in mouse. UniProtKB:Q61337-1, Ser-112/Ser-136, MOD:00046." [PMID:10949026, PMID:8929531, PMID:9346240, PRO:JAN]
enables
decreased
GO:0005515
protein binding
with
PR:P62258-1
PMID:12049737
decreased
GO:0005515
protein binding
with
PR:Q07817-1
PMID:12049737
decreased
GO:0005515
protein binding
with
PR:Q9CQV8
KCIP-1 (mouse)
PMID:12049737
decreased
GO:0005515
protein binding
with
PR:P63101
KCIP-1 (mouse)
PMID:12049737
PR:000044747
mBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in mouse." [PRO:DNx]
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:15280015
enables
GO:0005515
protein binding
with
PR:P04049
cRaf (human)
PMID:17011751
GO:0005515
protein binding
with
PR:P06803-2
PMID:17011751
GO:0005515
protein binding
with
PR:P15056
BRAF
PMID:17011751
GO:0005515
protein binding
with
PR:Q04759
hPRKCQ
PMID:17011751
located_in
GO:0031966
mitochondrial membrane
PMID:15280015
PR:000044748
rBAD/iso:1/UnMod
"A Bcl2-associated agonist of cell death isoform 1 unmodified form in rat." [PRO:DNx]
enables
GO:0005515
protein binding
with
PR:P53563-1
PMID:10195903
decreased
GO:0019902
phosphatase binding
relative to
PR:000026134
rBAD/iso:1/Phos:3
PMID:10195903
located_in
GO:0005739
mitochondrion
PMID:10195903
PR:O35147-1
rBAD/iso:Alpha
"A Bcl2-associated agonist of cell death isoform 1 that is encoded in the genome of rat." [PRO:JAN]
acts_upstream_of_or_within
GO:0043525
positive regulation of neuron apoptotic process
PMID:11161472
enables
GO:0005515
protein binding
with
PR:O88996-1
PMID:11161472