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Documentation
Protein Ontology report - catenin beta-1 isoform 1
PR:000002319 -
http://purl.obolibrary.org/obo/PR_000002319
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000002319
PRO name
catenin beta-1 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
CTNNB1/iso:1
Definition
"A catenin beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:P35222-1
or a 1:1 ortholog thereof." [PRO:JAN]
PRO Category
sequence
Parent
PR:000002198
catenin beta-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
23
Organism-Modification
24
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000002319
catenin beta-1 isoform 1, CTNNB1/iso:1
organism-sequence
PR:P35222-1
catenin beta-1 isoform 1 (human), hCTNNB1/iso:1
organism-modification
PR:000028553
catenin beta-1 isoform 1 acetylated 1 (human), hCTNNB1/iso:1/Ac:1
organism-modification
PR:000028794
catenin beta-1 isoform 1 acetylated 2 (human), hCTNNB1/iso:1/Ac:2
organism-modification
PR:000030192
catenin beta-1 isoform 1 phosphorylated 1 (human), hCTNNB1/iso:1/Phos:1
Yes
organism-modification
PR:000035770
catenin beta-1 isoform 1 phosphorylated 2 (human), hCTNNB1/iso:1/Phos:2
Yes
organism-modification
PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human), hCTNNB1/iso:1/Phos:3
Yes
organism-modification
PR:000035774
catenin beta-1 isoform 1 phosphorylated 4 (human), hCTNNB1/iso:1/Phos:4
Yes
organism-modification
PR:000036862
catenin beta-1 isoform 1 phosphorylated 5 (human), hCTNNB1/iso:1/Phos:5
Yes
organism-modification
PR:000036872
catenin beta-1 isoform 1 unphosphorylated 1 (human), hCTNNB1/iso:1/UnPhos:1
organism-modification
PR:000037181
catenin beta-1 isoform 1 phosphorylated 6 (human), hCTNNB1/iso:1/Phos:6
Yes
organism-modification
PR:000037185
catenin beta-1 isoform 1 unphosphorylated 2 (human), hCTNNB1/iso:1/UnPhos:2
Yes
organism-modification
PR:000037190
catenin beta-1 isoform 1 phosphorylated 7 (human), hCTNNB1/iso:1/Phos:7
Yes
organism-modification
PR:000037192
catenin beta-1 isoform 1 phosphorylated 8 (human), hCTNNB1/iso:1/Phos:8
Yes
organism-modification
PR:000037194
catenin beta-1 isoform 1 phosphorylated 9 (human), hCTNNB1/iso:1/Phos:9
Yes
organism-modification
PR:000037196
catenin beta-1 isoform 1 unphosphorylated 3 (human), hCTNNB1/iso:1/UnPhos:3
organism-modification
PR:000037229
catenin beta-1 isoform 1 phosphorylated 10 (human), hCTNNB1/iso:1/Phos:10
organism-modification
PR:000037515
catenin beta-1 isoform 1 phosphorylated 11 (human), hCTNNB1/iso:1/Phos:11
Yes
organism-modification
PR:000037772
catenin beta-1 isoform 1 unphosphorylated 4 (human), hCTNNB1/iso:1/UnPhos:4
organism-modification
PR:000037811
catenin beta-1 isoform 1 unphosphorylated 5 (human), hCTNNB1/iso:1/UnPhos:5
organism-modification
PR:000037813
catenin beta-1 isoform 1 unphosphorylated 6 (human), hCTNNB1/iso:1/UnPhos:6
organism-modification
PR:000044474
catenin beta-1 isoform 1 phosphorylated 12 (human), hCTNNB1/iso:1/Phos:12
Yes
organism-modification
PR:000044476
catenin beta-1 isoform 1 unphosphorylated 7 (human), hCTNNB1/iso:1/UnPhos:7
Yes
organism-modification
PR:000044478
catenin beta-1 isoform 1 phosphorylated 13 (human), hCTNNB1/iso:1/Phos:13
Yes
organism-modification
PR:000044510
catenin beta-1 isoform 1 phosphorylated 14 (human), hCTNNB1/iso:1/Phos:14
Yes
organism-sequence
PR:Q02248-1
catenin beta-1 isoform 1 (mouse), mCTNNB1/iso:1
organism-modification
PR:000037516
catenin beta-1 isoform 1 phosphorylated 11 (mouse), mCTNNB1/iso:1/Phos:11
modification
PR:000002862
catenin beta-1 isoform 1 unmodified form, CTNNB1/iso:1/UnMod
modification
PR:000028552
catenin beta-1 isoform 1 acetylated 1, CTNNB1/iso:1/Ac:1
organism-modification
PR:000028553
catenin beta-1 isoform 1 acetylated 1 (human), hCTNNB1/iso:1/Ac:1
modification
PR:000028793
catenin beta-1 isoform 1 acetylated 2, CTNNB1/iso:1/Ac:2
organism-modification
PR:000028794
catenin beta-1 isoform 1 acetylated 2 (human), hCTNNB1/iso:1/Ac:2
modification
PR:000030191
catenin beta-1 isoform 1 phosphorylated 1, CTNNB1/iso:1/Phos:1
organism-modification
PR:000030192
catenin beta-1 isoform 1 phosphorylated 1 (human), hCTNNB1/iso:1/Phos:1
Yes
modification
PR:000035769
catenin beta-1 isoform 1 phosphorylated 2, CTNNB1/iso:1/Phos:2
organism-modification
PR:000035770
catenin beta-1 isoform 1 phosphorylated 2 (human), hCTNNB1/iso:1/Phos:2
Yes
modification
PR:000035771
catenin beta-1 isoform 1 phosphorylated 3, CTNNB1/iso:1/Phos:3
organism-modification
PR:000035772
catenin beta-1 isoform 1 phosphorylated 3 (human), hCTNNB1/iso:1/Phos:3
Yes
modification
PR:000035773
catenin beta-1 isoform 1 phosphorylated 4, CTNNB1/iso:1/Phos:4
organism-modification
PR:000035774
catenin beta-1 isoform 1 phosphorylated 4 (human), hCTNNB1/iso:1/Phos:4
Yes
modification
PR:000036861
catenin beta-1 isoform 1 phosphorylated 5, CTNNB1/iso:1/Phos:5
organism-modification
PR:000036862
catenin beta-1 isoform 1 phosphorylated 5 (human), hCTNNB1/iso:1/Phos:5
Yes
modification
PR:000036871
catenin beta-1 isoform 1 unphosphorylated 1, CTNNB1/iso:1/UnPhos:1
organism-modification
PR:000036872
catenin beta-1 isoform 1 unphosphorylated 1 (human), hCTNNB1/iso:1/UnPhos:1
modification
PR:000037180
catenin beta-1 isoform 1 phosphorylated 6, CTNNB1/iso:1/Phos:6
organism-modification
PR:000037181
catenin beta-1 isoform 1 phosphorylated 6 (human), hCTNNB1/iso:1/Phos:6
Yes
modification
PR:000037184
catenin beta-1 isoform 1 unphosphorylated 2, CTNNB1/iso:1/UnPhos:2
organism-modification
PR:000037185
catenin beta-1 isoform 1 unphosphorylated 2 (human), hCTNNB1/iso:1/UnPhos:2
Yes
modification
PR:000037189
catenin beta-1 isoform 1 phosphorylated 7, CTNNB1/iso:1/Phos:7
organism-modification
PR:000037190
catenin beta-1 isoform 1 phosphorylated 7 (human), hCTNNB1/iso:1/Phos:7
Yes
modification
PR:000037191
catenin beta-1 isoform 1 phosphorylated 8, CTNNB1/iso:1/Phos:8
organism-modification
PR:000037192
catenin beta-1 isoform 1 phosphorylated 8 (human), hCTNNB1/iso:1/Phos:8
Yes
modification
PR:000037193
catenin beta-1 isoform 1 phosphorylated 9, CTNNB1/iso:1/Phos:9
organism-modification
PR:000037194
catenin beta-1 isoform 1 phosphorylated 9 (human), hCTNNB1/iso:1/Phos:9
Yes
modification
PR:000037195
catenin beta-1 isoform 1 unphosphorylated 3, CTNNB1/iso:1/UnPhos:3
organism-modification
PR:000037196
catenin beta-1 isoform 1 unphosphorylated 3 (human), hCTNNB1/iso:1/UnPhos:3
modification
PR:000037228
catenin beta-1 isoform 1 phosphorylated 10, CTNNB1/iso:1/Phos:10
organism-modification
PR:000037229
catenin beta-1 isoform 1 phosphorylated 10 (human), hCTNNB1/iso:1/Phos:10
modification
PR:000037514
catenin beta-1 isoform 1 phosphorylated 11, CTNNB1/iso:1/Phos:11
organism-modification
PR:000037515
catenin beta-1 isoform 1 phosphorylated 11 (human), hCTNNB1/iso:1/Phos:11
Yes
organism-modification
PR:000037516
catenin beta-1 isoform 1 phosphorylated 11 (mouse), mCTNNB1/iso:1/Phos:11
modification
PR:000037771
catenin beta-1 isoform 1 unphosphorylated 4, CTNNB1/iso:1/UnPhos:4
organism-modification
PR:000037772
catenin beta-1 isoform 1 unphosphorylated 4 (human), hCTNNB1/iso:1/UnPhos:4
modification
PR:000037810
catenin beta-1 isoform 1 unphosphorylated 5, CTNNB1/iso:1/UnPhos:5
organism-modification
PR:000037811
catenin beta-1 isoform 1 unphosphorylated 5 (human), hCTNNB1/iso:1/UnPhos:5
modification
PR:000037812
catenin beta-1 isoform 1 unphosphorylated 6, CTNNB1/iso:1/UnPhos:6
organism-modification
PR:000037813
catenin beta-1 isoform 1 unphosphorylated 6 (human), hCTNNB1/iso:1/UnPhos:6
modification
PR:000044473
catenin beta-1 isoform 1 phosphorylated 12, CTNNB1/iso:1/Phos:12
organism-modification
PR:000044474
catenin beta-1 isoform 1 phosphorylated 12 (human), hCTNNB1/iso:1/Phos:12
Yes
modification
PR:000044475
catenin beta-1 isoform 1 unphosphorylated 7, CTNNB1/iso:1/UnPhos:7
organism-modification
PR:000044476
catenin beta-1 isoform 1 unphosphorylated 7 (human), hCTNNB1/iso:1/UnPhos:7
Yes
modification
PR:000044477
catenin beta-1 isoform 1 phosphorylated 13, CTNNB1/iso:1/Phos:13
organism-modification
PR:000044478
catenin beta-1 isoform 1 phosphorylated 13 (human), hCTNNB1/iso:1/Phos:13
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000030192
hCTNNB1/iso:1/Phos:1
UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046
"A catenin beta-1 isoform 1 phosphorylated 1 in human. Phosphorylation at Ser-663 is found in many human colon cancer cells and tissues, which display a high PAK1 activity, or in response to Wnt3a stimulation. Ser-675 can be phosphorylated by either PAK1 or PKA. UniProtKB:P35222-1, Ser-663/Ser-675, MOD:00046." [PMID:22369945, PRO:IC]
acts_upstream_of_or_within
GO:0016055
Wnt signaling pathway
PMID:22369945
enables
increased
GO:0003713
transcription coactivator activity
relative to
PR:000002862
CTNNB1/iso:1/UnMod
PMID:22369945
PR:000035770
hCTNNB1/iso:1/Phos:2
UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 and/or Tyr-333, MOD:00048)
"A catenin beta-1 isoform 1 phosphorylated 2 in human. Tyr-64 is the major phosphorylation site for PTK6. UniProtKB:P35222-1, Tyr-64, MOD:00048|Tyr-142, MOD:00048|(Tyr-331, MOD:00048 or Tyr-333, MOD:00048)." [PMID:20026641, PRO:IC]
located_in
GO:0005634
nucleus
PMID:20026641
PR:000035772
hCTNNB1/iso:1/Phos:3
UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047
"A catenin beta-1 isoform 1 phosphorylated 3 in human. Phosphorylation at Ser-45 is needed for the other sites to be phosphorylated. UniProtKB:P35222-1, Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047." [PMID:11955436, PMID:12000790, PMID:16199882, PRO:IC]
enables
NOT
GO:0005515
protein binding
with
PR:Q9Y297
BTRC
PMID:10074433
NOT
GO:0005515
protein binding
with
PR:Q9UKB1
BTRCP2
PMID:10074433
PR:000035774
hCTNNB1/iso:1/Phos:4
UniProtKB:P35222-1, Ser-45, MOD:00046
"A catenin beta-1 isoform 1 phosphorylated 4 in human. UniProtKB:P35222-1, Ser-45, MOD:00046." [PMID:11955436, PMID:16199882, PRO:IC]
enables
increased
GO:0005515
protein binding
with
PR:P12830
CAM 120/80 (human)
PMID:12051714
;
PMID:20419129
;
PMID:23606879
increased
GO:0005515
protein binding
with
PR:P49841
GSK-3 beta (human)
PMID:12051714
;
PMID:20419129
;
PMID:23606879
located_in
GO:0005634
nucleus
PMID:20419129
PR:000036862
hCTNNB1/iso:1/Phos:5
UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046
"A catenin beta-1 isoform 1 phosphorylated 5 in human. UniProtKB:P35222-1, Ser-552/Ser-675, MOD:00046." [PMID:16476742, PRO:IC]
enables
increased
GO:0003713
transcription coactivator activity
relative to
PR:000036872
hCTNNB1/iso:1/UnPhos:1
PMID:16476742
increased
GO:0005515
protein binding
relative to
PR:000036872
hCTNNB1/iso:1/UnPhos:1
PMID:16476742
PR:000037181
hCTNNB1/iso:1/Phos:6
UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047
"A catenin beta-1 isoform 1 phosphorylated 6 in human. UniProtKB:P35222-1, Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:19667122, PRO:IC]
located_in
decreased
GO:0005912
adherens junction
relative to
PR:000037185
hCTNNB1/iso:1/UnPhos:2
PMID:19667122
PR:000037185
hCTNNB1/iso:1/UnPhos:2
UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291
"A catenin beta-1 isoform 1 unphosphorylated 2 in human. UniProtKB:P35222-1, Ser-37/Thr-41, PR:000026291." [PRO:CNA]
enables
GO:0003713
transcription coactivator activity
PMID:20419129
GO:0005515
protein binding
PMID:20419129
located_in
GO:0005634
nucleus
PMID:20419129
PR:000037190
hCTNNB1/iso:1/Phos:7
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
"A catenin beta-1 isoform 1 phosphorylated 7 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047." [PMID:14500351, PRO:IC]
acts_upstream_of_or_within
decreased
GO:0007155
cell adhesion
relative to
PR:000037811
hCTNNB1/iso:1/UnPhos:5
PMID:19667122
GO:0010631
epithelial cell migration
PMID:21152425
decreased
GO:0034333
adherens junction assembly
relative to
PR:000037811
hCTNNB1/iso:1/UnPhos:5
PMID:19667122
enables
decreased
GO:0003713
transcription coactivator activity
relative to
PR:000037185
hCTNNB1/iso:1/UnPhos:2
PMID:20419129
NOT
GO:0005515
protein binding
with
PR:Q9HCS4
HMG box transcription factor 3 (human)
PMID:21152425
NOT
GO:0005515
protein binding
with
PR:Q9NQB0
HMG box transcription factor 4 (human)
PMID:21152425
NOT
GO:0005515
protein binding
with
PR:Q9UJU2
hLEF1
PMID:21152425
NOT
GO:0005515
protein binding
with
PR:Q9Y297
BTRC
PMID:21152425
NOT
GO:0005515
protein binding
with
PR:P12830
CAM 120/80 (human)
PMID:21152425
NOT
GO:0005515
protein binding
PMID:21152425
located_in
GO:0005737
cytoplasm
PMID:20419129
decreased
GO:0005912
adherens junction
relative to
PR:000037811
hCTNNB1/iso:1/UnPhos:5
PMID:19667122
PR:000037192
hCTNNB1/iso:1/Phos:8
UniProtKB:P35222-1, Tyr-333, MOD:00048
"A catenin beta-1 isoform 1 phosphorylated 8 in human. UniProtKB:P35222-1, Tyr-333, MOD:00048." [PMID:22056988, PRO:IC]
acts_upstream_of_or_within
GO:0007173
epidermal growth factor receptor signaling pathway
PMID:22056988
enables
GO:0003713
transcription coactivator activity
PMID:22056988
GO:0005515
protein binding
PMID:22056988
located_in
GO:0005634
nucleus
PMID:22056988
PR:000037194
hCTNNB1/iso:1/Phos:9
UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048
"A catenin beta-1 isoform 1 phosphorylated 9 in human. UniProtKB:P35222-1, Tyr-86/Tyr-654, MOD:00048." [PMID:10593980, PRO:IC]
enables
increased
GO:0017025
TBP-class protein binding
with
PR:P20226
GTF2D1
PMID:11279024
decreased
GO:0045296
cadherin binding
relative to
PR:000037196
hCTNNB1/iso:1/UnPhos:3
PMID:11279024
PR:000037515
hCTNNB1/iso:1/Phos:11
UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046
"A catenin beta-1 isoform 1 phosphorylated 11 in human. UniProtKB:P35222-1, Ser-33/Ser-37, MOD:00046." [PMID:20307497, PRO:IC, PRO:KER]
acts_upstream_of_or_within
decreased
GO:0008283
cell population proliferation
relative to
PR:000037772
hCTNNB1/iso:1/UnPhos:4
PMID:20307497
decreased
GO:0060070
canonical Wnt signaling pathway
relative to
PR:000037772
hCTNNB1/iso:1/UnPhos:4
PMID:20307497
enables
decreased
GO:0003713
transcription coactivator activity
relative to
PR:000037772
hCTNNB1/iso:1/UnPhos:4
PMID:20307497
increased
GO:0005515
protein binding
relative to
PR:000037772
hCTNNB1/iso:1/UnPhos:4
PMID:16996060
;
PMID:21152425
;
PMID:23071615
PR:000044474
hCTNNB1/iso:1/Phos:12
UniProtKB:P35222-1, Thr-393, MOD:00047
"A catenin beta-1 isoform 1 phosphorylated 12 in human. UniProtKB:P35222-1, Thr-393, MOD:00047." [PMID:12700239, PMID:19565571, PRO:KER]
acts_upstream_of_or_within
GO:0016055
Wnt signaling pathway
PMID:12700239
GO:0045944
positive regulation of transcription by RNA polymerase II
PMID:12700239
enables
decreased
GO:0005515
protein binding
with
PR:Q9YGY0
axin
PMID:19565571
PR:000044476
hCTNNB1/iso:1/UnPhos:7
UniProtKB:P35222-1, Thr-393, PR:000026291
"A catenin beta-1 isoform 1 unphosphorylated 7 in human. UniProtKB:P35222-1, Thr-393, PR:000026291." [PMID:12700239, PMID:19565571, PRO:KER]
enables
GO:0005515
protein binding
with
PR:Q9YGY0
axin
PMID:19565571
PR:000044478
hCTNNB1/iso:1/Phos:13
UniProtKB:P35222-1, Tyr-654, MOD:00048
"A catenin beta-1 isoform 1 phosphorylated 13 in human. UniProtKB:P35222-1, Tyr-654, MOD:00048." [PMID:23640056, PRO:KER]
enables
GO:0003713
transcription coactivator activity
PMID:23640056
PR:000044510
hCTNNB1/iso:1/Phos:14
UniProtKB:P35222-1, Ser-552, MOD:00046
"A catenin beta-1 isoform 1 (human) that has been phosphorylated on a Ser residue within the 14-3-3 recognition motif. UniProtKB:P35222-1, Ser-552, MOD:00046." [PMID:17287208, PRO:CNA]
enables
GO:0071889
14-3-3 protein binding
with
PR:P63104
hYWHAZ
PMID:17287208
