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Protein Ontology report - aurora kinase B
PR:000004517 - http://purl.obolibrary.org/obo/PR_000004517
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000004517   
  PRO nameaurora kinase B 
  Synonyms
PRO-Short-label: EXACT:AURKB
Gene-based: RELATED:AIK2 | AIM1 | AIRK2 | ARK2 | STK12
Other: EXACT:AIM-1 | ARK-2 | aurora 1 | aurora- and Ipl1-like midbody-associated protein 1 | aurora-related kinase 2 | aurora/IPL1-related kinase 2 | serine/threonine-protein kinase 12 | serine/threonine-protein kinase 5 | serine/threonine-protein kinase aurora-B
RELATED:STK-1 | Stk1 | Stk5
  Definition"An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000035365
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 9                                        
         Sequence0                                                  Organism-Sequence 5                                        
         Modification3                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1937
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000004517 aurora kinase B, AURKB

organism-gene


PR:000060242 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe), Spom-AURKB

organism-gene


PR:O01427 aurora/IPL1-related protein kinase 2 (worm), AURKB (worm)

organism-gene


PR:O55099 aurora kinase B (rat), rAURKB

organism-gene


PR:O59790 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe 972h-), Spom972h-AURKB

organism-gene


PR:O70126 aurora kinase B (mouse), mAURKB

organism-gene


PR:Q6DE08 aurora kinase B-A (frog), frog-AURKB

organism-gene


PR:Q6NW76 aurora kinase B (zebrafish), z-AURKB

organism-gene


PR:Q96GD4 aurora kinase B (human), hAURKB
Yes
organism-sequence


PR:Q96GD4-1 aurora kinase B isoform h1 (human), hAURKB/iso:h1

organism-sequence


PR:Q96GD4-2 aurora kinase B isoform h2 (human), hAURKB/iso:h2

organism-sequence


PR:Q96GD4-3 aurora kinase B isoform h3 (human), hAURKB/iso:h3

organism-sequence


PR:Q96GD4-4 aurora kinase B isoform h4 (human), hAURKB/iso:h4

organism-sequence


PR:Q96GD4-5 aurora kinase B isoform h5 (human), hAURKB/iso:h5

organism-modification


PR:000035661 aurora kinase B unphosphorylated form (human), hAURKB/PhosRes-
Yes
organism-modification


PR:000035663 aurora kinase B phosphorylated 1 (human), hAURKB/Phos:1
Yes
organism-modification


PR:000046026 aurora kinase B phosphorylated 2 (human), hAURKB/Phos:2

organism-modification


PR:000046440 aurora kinase B sumoylated 1 (human), hAURKB/Sumo:1

organism-modification


PR:000075980 aurora kinase B methylated 1 (human), hAURKB/Me:1

organism-modification


PR:000077527 aurora kinase B cysteinylated 1 (human), hAURKB/Cyst:1

organism-gene


PR:Q9VKN7 aurora kinase B (fruit fly), fly-AURKB

modification


PR:000019090 aurora kinase B, initiator methionine removed form, AURKB/InitMet-

modification


PR:000035660 aurora kinase B unphosphorylated form, AURKB/PhosRes-

organism-modification


PR:000035661 aurora kinase B unphosphorylated form (human), hAURKB/PhosRes-
Yes
modification


PR:000035662 aurora kinase B phosphorylated 1, AURKB/Phos:1

organism-modification


PR:000035663 aurora kinase B phosphorylated 1 (human), hAURKB/Phos:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035661
hAURKB/PhosRes-
 enablesGO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:000035663
hAURKB/Phos:1
UniProtKB:Q96GD4, Ser-331, MOD:00046 | hAURKB active form		 acts_upstream_of_or_withinincreased GO:0007059 chromosome segregation relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0031577 spindle checkpoint signaling relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
increased GO:0051310 metaphase chromosome alignment relative to PR:000035661 hAURKB/PhosRes- PMID:22024163
enablesincreased GO:0004672 protein kinase activity relative to PR:000035661 hAURKB/PhosRes- PMID:17276342; PMID:22024163
GO:0005515 protein binding PMID:22024163
located_inGO:0000776 kinetochore PMID:22024163
PR:Q96GD4
hAURKB
AIK2 | AIM1 | AIRK2 | ARK2 | AURKB | STK1 | STK12 | STK5 | AIM-1 (human) | ARK-2 (human) | aurora 1 (human) | aurora- and IPL1-like midbody-associated protein 1 (human) | aurora-related kinase 2 (human) | aurora/IPL1-related kinase 2 (human) | serine/threonine-protein kinase 12 (human) | serine/threonine-protein kinase 5 (human) | serine/threonine-protein kinase aurora-B (human) | STK-1 (human) (BROAD)		 acts_upstream_of_or_withinGO:0007059 chromosome segregation PMID:12719470
GO:0008608 attachment of spindle microtubules to kinetochore PMID:12719470; PMID:15592459
GO:0031577 spindle checkpoint signaling PMID:12719470
GO:0034501 protein localization to kinetochore PMID:12719470; PMID:17617734; PMID:22732840
NOT GO:0051306 mitotic sister chromatid separation PMID:12719470
GO:0051310 metaphase chromosome alignment PMID:12719470; PMID:22732840
GO:0071459 protein localization to chromosome, centromeric region PMID:12719470; PMID:21658950
GO:0140014 mitotic nuclear division PMID:12719470
enablesGO:0004672 protein kinase activity PMID:12719470
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P06493 CDC2 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:P68431 H3C1 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q13043 hSTK4 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q15208 hSTK38 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q53HL2 CDCA8 BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human) BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding with PR:Q9NQS7 hINCENP BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
GO:0005515 protein binding BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
located_inGO:0000776 kinetochore PMID:20624902
GO:0000779 condensed chromosome, centromeric region PMID:12719470; PMID:15917996
GO:0000939 inner kinetochore PMID:15592459
GO:0030496 midbody PMID:15917996
GO:0051233 spindle midzone PMID:15917996