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Protein Ontology report - epidermal growth factor receptor
PR:000006933 - http://purl.obolibrary.org/obo/PR_000006933
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000006933   
  PRO nameepidermal growth factor receptor 
  Synonyms
PRO-Short-label: EXACT:EGFR
Gene-based: RELATED:ERBB | ERBB1 | HER1
Other: EXACT:proto-oncogene c-ErbB-1 | receptor tyrosine-protein kinase erbB-1
  Definition"An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000001812 EGF receptor type tyrosine-protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification3                                                  Organism-Modification 52                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1797
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000006933 epidermal growth factor receptor, EGFR

organism-gene


PR:P00533 epidermal growth factor receptor (human), hEGFR

organism-sequence


PR:P00533-1 epidermal growth factor receptor isoform 1 (human), hEGFR/iso:1

organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-sequence


PR:P00533-2 epidermal growth factor receptor isoform h2 (human), hEGFR/iso:h2

organism-sequence


PR:P00533-3 epidermal growth factor receptor isoform h3 (human), hEGFR/iso:h3

organism-sequence


PR:P00533-4 epidermal growth factor receptor isoform h4 (human), hEGFR/iso:h4

organism-modification


PR:000028422 epidermal growth factor receptor, signal peptide removed form (human), hEGFR/SigPep-

Yes
organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000047261 epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human), hEGFR/SigPep-/Phos:1

organism-modification


PR:000047262 epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human), hEGFR/SigPep-/Phos:2

organism-modification


PR:000049849 epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human), hEGFR/SigPep-/Phos:3
Yes
organism-modification


PR:000049850 epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human), hEGFR/SigPep-/UnPhos:3

organism-modification


PR:000049851 epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human), hEGFR/SigPep-/Phos:4
Yes
organism-modification


PR:000049852 epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human), hEGFR/SigPep-/UnPhos:4

organism-modification


PR:000051027 epidermal growth factor receptor N-glycosylated 1 (human), hEGFR/NGlyco:1

organism-modification


PR:000051028 epidermal growth factor receptor N-glycosylated 2 (human), hEGFR/NGlyco:2

organism-modification


PR:000051029 epidermal growth factor receptor N-glycosylated 3 (human), hEGFR/NGlyco:3

organism-modification


PR:000051030 epidermal growth factor receptor N-glycosylated 4 (human), hEGFR/NGlyco:4

organism-modification


PR:000051031 epidermal growth factor receptor N-glycosylated 5 (human), hEGFR/NGlyco:5

organism-modification


PR:000051032 epidermal growth factor receptor N-glycosylated 6 (human), hEGFR/NGlyco:6

organism-modification


PR:000051033 epidermal growth factor receptor N-glycosylated 7 (human), hEGFR/NGlyco:7

organism-modification


PR:000051034 epidermal growth factor receptor N-glycosylated 8 (human), hEGFR/NGlyco:8

organism-modification


PR:000051035 epidermal growth factor receptor N-glycosylated 9 (human), hEGFR/NGlyco:9

organism-modification


PR:000051036 epidermal growth factor receptor N-glycosylated 10 (human), hEGFR/NGlyco:10

organism-modification


PR:000051037 epidermal growth factor receptor N-glycosylated 11 (human), hEGFR/NGlyco:11

organism-modification


PR:000060975 epidermal growth factor receptor sequence variant A289V, signal peptide removed phosphorylated 1 (human), hEGFR/var:A289V/SigPep-/Phos:1

organism-modification


PR:000060991 epidermal growth factor receptor sequence variant G719C, signal peptide removed phosphorylated 1 (human), hEGFR/var:G719C/SigPep-/Phos:1

organism-modification


PR:000061152 epidermal growth factor receptor sequence variant G719S, signal peptide removed form (human), hEGFR/var:G719S/SigPep-

organism-modification


PR:000061330 epidermal growth factor receptor sequence variant A289D, signal peptide removed phosphorylated 1 (human), hEGFR/var:A289D/SigPep-/Phos:1

organism-modification


PR:000061460 epidermal growth factor receptor sequence variant T263P, signal peptide removed form (human), hEGFR/var:T263P/SigPep-

organism-modification


PR:000061481 epidermal growth factor receptor sequence variant A289T, signal peptide removed form (human), hEGFR/var:A289T/SigPep-

organism-modification


PR:000061628 epidermal growth factor receptor sequence variant G719A, signal peptide removed phosphorylated 1 (human), hEGFR/var:G719A/SigPep-/Phos:1

organism-modification


PR:000061782 epidermal growth factor receptor sequence variant A289V, signal peptide removed form (human), hEGFR/var:A289V/SigPep-

organism-modification


PR:000061821 epidermal growth factor receptor sequence variant R108K, signal peptide removed form (human), hEGFR/var:R108K/SigPep-

organism-modification


PR:000061883 epidermal growth factor receptor sequence variant A289T, signal peptide removed phosphorylated 1 (human), hEGFR/var:A289T/SigPep-/Phos:1

organism-modification


PR:000062003 epidermal growth factor receptor sequence variant L858R, signal peptide removed phosphorylated 1 (human), hEGFR/var:L858R/SigPep-/Phos:1

organism-modification


PR:000062217 epidermal growth factor receptor, signal peptide removed phosphorylated 5 (human), hEGFR/SigPep-/Phos:5

organism-modification


PR:000062715 epidermal growth factor receptor sequence variant L861Q, signal peptide removed phosphorylated 1 (human), hEGFR/var:L861Q/SigPep-/Phos:1

organism-modification


PR:000062731 epidermal growth factor receptor sequence variant G719A, signal peptide removed form (human), hEGFR/var:G719A/SigPep-

organism-modification


PR:000062845 epidermal growth factor receptor sequence variant G598V, signal peptide removed form (human), hEGFR/var:G598V/SigPep-

organism-modification


PR:000063380 epidermal growth factor receptor sequence variant A289D, signal peptide removed form (human), hEGFR/var:A289D/SigPep-

organism-modification


PR:000063452 epidermal growth factor receptor sequence variant G598V, signal peptide removed phosphorylated 1 (human), hEGFR/var:G598V/SigPep-/Phos:1

organism-modification


PR:000063536 epidermal growth factor receptor sequence variant G719S, signal peptide removed phosphorylated 1 (human), hEGFR/var:G719S/SigPep-/Phos:1

organism-modification


PR:000063584 epidermal growth factor receptor sequence variant L861Q, signal peptide removed form (human), hEGFR/var:L861Q/SigPep-

organism-modification


PR:000063750 epidermal growth factor receptor sequence variant G719C, signal peptide removed form (human), hEGFR/var:G719C/SigPep-

organism-modification


PR:000063826 epidermal growth factor receptor sequence variant R108K, signal peptide removed phosphorylated 1 (human), hEGFR/var:R108K/SigPep-/Phos:1

organism-modification


PR:000064048 epidermal growth factor receptor sequence variant T263P, signal peptide removed phosphorylated 1 (human), hEGFR/var:T263P/SigPep-/Phos:1

organism-modification


PR:000064466 epidermal growth factor receptor sequence variant L858R, signal peptide removed form (human), hEGFR/var:L858R/SigPep-

organism-modification


PR:000064533 epidermal growth factor receptor, signal peptide removed phosphorylated 6 (human), hEGFR/SigPep-/Phos:6

organism-modification


PR:000066084 epidermal growth factor receptor deaminated 1 (human), hEGFR/Deam:1

organism-modification


PR:000083012 epidermal growth factor receptor phosphorylated 1 (human), hEGFR/Phos:1

organism-gene


PR:Q01279 epidermal growth factor receptor (mouse), mEGFR

organism-sequence


PR:Q01279-1 epidermal growth factor receptor isoform 1 (mouse), mEGFR/iso:1

organism-modification


PR:000044844 epidermal growth factor receptor phosphorylated form (mouse), mEGFR/PhosRes+

organism-modification


PR:000049815 epidermal growth factor receptor, signal peptide removed form (mouse), mEGFR/SigPep-

organism-modification


PR:000049816 epidermal growth factor receptor, signal peptide removed phosphorylated 1 (mouse), mEGFR/SigPep-/Phos:1

organism-modification


PR:000049817 epidermal growth factor receptor, signal peptide removed phosphorylated 2 (mouse), mEGFR/SigPep-/Phos:2

organism-modification


PR:000049818 epidermal growth factor receptor, signal peptide removed phosphorylated 3 (mouse), mEGFR/SigPep-/Phos:3

organism-modification


PR:000049819 epidermal growth factor receptor, signal peptide removed phosphorylated 4 (mouse), mEGFR/SigPep-/Phos:4

sequence


PR:000027474 epidermal growth factor receptor isoform 1, EGFR/iso:1

organism-sequence


PR:P00533-1 epidermal growth factor receptor isoform 1 (human), hEGFR/iso:1

organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-sequence


PR:Q01279-1 epidermal growth factor receptor isoform 1 (mouse), mEGFR/iso:1

modification


PR:000027476 epidermal growth factor receptor isoform 1, signal peptide removed form, EGFR/iso:1/SigPep-

modification


PR:000027478 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1, EGFR/iso:1/SigPep-/Phos:1

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
modification


PR:000019753 epidermal growth factor receptor, signal peptide removed form, EGFR/SigPep-

modification


PR:000027476 epidermal growth factor receptor isoform 1, signal peptide removed form, EGFR/iso:1/SigPep-

modification


PR:000027478 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1, EGFR/iso:1/SigPep-/Phos:1

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000028422 epidermal growth factor receptor, signal peptide removed form (human), hEGFR/SigPep-

Yes
organism-modification


PR:000027477 epidermal growth factor receptor isoform 1, signal peptide removed form (human), hEGFR/iso:1/SigPep-

organism-modification


PR:000027479 epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human), hEGFR/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000047261 epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human), hEGFR/SigPep-/Phos:1

organism-modification


PR:000047262 epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human), hEGFR/SigPep-/Phos:2

organism-modification


PR:000049849 epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human), hEGFR/SigPep-/Phos:3
Yes
organism-modification


PR:000049850 epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human), hEGFR/SigPep-/UnPhos:3

organism-modification


PR:000049851 epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human), hEGFR/SigPep-/Phos:4
Yes
organism-modification


PR:000049852 epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human), hEGFR/SigPep-/UnPhos:4

organism-modification


PR:000049815 epidermal growth factor receptor, signal peptide removed form (mouse), mEGFR/SigPep-

organism-modification


PR:000049816 epidermal growth factor receptor, signal peptide removed phosphorylated 1 (mouse), mEGFR/SigPep-/Phos:1

organism-modification


PR:000049817 epidermal growth factor receptor, signal peptide removed phosphorylated 2 (mouse), mEGFR/SigPep-/Phos:2

organism-modification


PR:000049818 epidermal growth factor receptor, signal peptide removed phosphorylated 3 (mouse), mEGFR/SigPep-/Phos:3

organism-modification


PR:000049819 epidermal growth factor receptor, signal peptide removed phosphorylated 4 (mouse), mEGFR/SigPep-/Phos:4

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EGFR forms found in complexes   

EGFR Component
 Complexes
PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048 | PRO_0000016665, Tyr-869, MOD:00048
"An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD]		 acts_upstream_of_or_withinGO:0034504 protein localization to nucleus PMID:18789131
located_inGO:0005634 nucleus PMID:18789131
PR:000049849 hEGFR/SigPep-/Phos:3
UniProtKB:P00533, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 | UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
decreased GO:0005515 protein binding relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
PR:000049851 hEGFR/SigPep-/Phos:4
UniProtKB:P00533, 25-1210, Ser-768, MOD:00046 | UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046." [PMID:10347170, PRO:KER]		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170