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Protein Ontology report - TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
PR:000021904 - http://purl.obolibrary.org/obo/PR_000021904
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000021904   
  PRO nameTGF-beta 1 sequence variant R218C, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/var:R218C/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950
Other: EXACT:TGF-beta 1 sequence variant 3, signal peptide removed form (human)
  Definition"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN] 
  PRO Categoryorganism-modification 
  ParentPR:000000400 TGF-beta 1 sequence variant R218C (human)
PR:000049430 transforming growth factor beta-1, signal peptide removed form (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-modification


PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human), hTGFB1/var:R218C/SigPep-

organism-modification


PR:000000621 TGF-beta 1 sequence variant R218C cleaved 1 (human), hTGFB1/var:R218C/Clv:1
Yes
organism-modification


PR:000000622 TGF-beta 1 sequence variant R218C cleaved 2 (human), hTGFB1/var:R218C/Clv:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000621 hTGFB1/var:R218C/Clv:1
UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 1 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463; PMID:12493741; PMID:12843182
enablesGO:0005160 transforming growth factor beta receptor binding PMID:11278244
increased GO:0008083 growth factor activity relative to PR:000000616 TGF-beta 1 active protein PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity PMID:11062463; PMID:12493741; PMID:12843182
located_inGO:0005615 extracellular space PMID:11062463; PMID:12493741; PMID:12843182
PR:000000622 hTGFB1/var:R218C/Clv:2
UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950 | TGF-beta 1 sequence variant 3 cleaved 2 (human)
"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]		 located_inSO:0001561 polypeptide_partial_loss_of_function PMID:11278244