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Protein Ontology report - retinoic acid receptor alpha isoform 1

PR:000022009 - http://purl.obolibrary.org/obo/PR_000022009

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000022009

PRO name

retinoic acid receptor alpha isoform 1

Synonyms

PRO-Short-label:	EXACT:	RARA/iso:1
Other:	EXACT:	retinoic acid receptor isoform alpha-1

Definition

"A retinoic acid receptor alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11416-1 or a 1:1 ortholog thereof." [PRO:HJD]

PRO Category

sequence

Parent

PR:000013736 retinoic acid receptor alpha

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	1	Organism-Modification	2

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000022009 retinoic acid receptor alpha isoform 1, RARA/iso:1

organism-sequence

PR:P10276-1 retinoic acid receptor alpha isoform 1 (human), hRARA/iso:1

organism-modification

PR:000026078 retinoic acid receptor alpha isoform 1 phosphorylated 1 (human), hRARA/iso:1/Phos:1

organism-sequence

PR:P11416-1 retinoic acid receptor alpha isoform 1 (mouse), mRARA/iso:1

Yes

organism-modification

PR:000026077 retinoic acid receptor alpha isoform 1 phosphorylated 1 (mouse), mRARA/iso:1/Phos:1

modification

PR:000026076 retinoic acid receptor alpha isoform 1 phosphorylated 1, RARA/iso:1/Phos:1

organism-modification

PR:000026077 retinoic acid receptor alpha isoform 1 phosphorylated 1 (mouse), mRARA/iso:1/Phos:1

organism-modification

PR:000026078 retinoic acid receptor alpha isoform 1 phosphorylated 1 (human), hRARA/iso:1/Phos:1

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:P11416-1 mRARA/iso:1 mRARalpha1 "A retinoic acid receptor alpha isoform 1 that is encoded in the genome of mouse." [PRO:HJD]	acts_upstream_of_or_within	GO:0000122 negative regulation of transcription by RNA polymerase II	PMID:8152920
		GO:0006355 regulation of DNA-templated transcription	PMID:12101409
		GO:0006355 regulation of DNA-templated transcription	PMID:12101409
		GO:0045892 negative regulation of DNA-templated transcription	PMID:11641275
		GO:0045947 negative regulation of translational initiation	MGI:3803427; PMID:18495661
	enables	GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding	MGI:3053708; PMID:1655807
		GO:0003677 DNA binding	PMID:15528198
		GO:0003677 DNA binding	PMID:15528198
		GO:0003700 DNA-binding transcription factor activity	PMID:8152920
		GO:0003700 DNA-binding transcription factor activity	PMID:8152920
		GO:0004879 nuclear receptor activity	PMID:15322135
		GO:0004879 nuclear receptor activity	PMID:15322135
		GO:0005515 protein binding	PMID:10531331
		GO:0005515 protein binding	PMID:10531331
		GO:0043565 sequence-specific DNA binding	PMID:17928865
	located_in	GO:0005634 nucleus with CHEBI:15367	PMID:12079996
		GO:0005737 cytoplasm	PMID:12079996
		GO:0030425 dendrite	MGI:3803427; PMID:18495661
		GO:0043025 neuronal cell body	MGI:3803427; PMID:18495661