back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - eukaryotic serine palmitoyltransferase
PR:000026126 - http://purl.obolibrary.org/obo/PR_000026126
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026126   
  PRO nameeukaryotic serine palmitoyltransferase 
  Synonyms
PRO-Short-label: EXACT:fam:euk-SPT
Other: SPT (BROAD)
  Definition"A PLP-dependent alpha-oxoamine synthase that is involved in sphingolipid biosynthesis in Eukaryota, particularly in the condensation of L-serine and palmitoyl-CoA." [PMID:12782147, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000026124 PLP-dependent alpha-oxoamine synthase
PR:000036194 eukaryotic protein
  TaxonNCBITaxon:2759 Eukaryota
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 13                                        
         Sequence2                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000026126 eukaryotic serine palmitoyltransferase, fam:euk-SPT

gene


PR:000015596 serine palmitoyltransferase 1, SPTLC1

organism-gene


PR:D4A2H2 serine palmitoyltransferase 1 (rat), rSPTLC1

organism-gene


PR:O15269 serine palmitoyltransferase 1 (human), hSPTLC1

Yes
organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human), hSPTLC1/iso:1

organism-sequence


PR:O15269-2 serine palmitoyltransferase 1 isoform h2 (human), hSPTLC1/iso:h2

organism-modification


PR:000045580 serine palmitoyltransferase 1 phosphorylated 1 (human), hSPTLC1/Phos:1

organism-modification


PR:000061744 serine palmitoyltransferase 1 pyridoxal phosphate lysine form (human), hSPTLC1/PyrdoxLys+

organism-modification


PR:000075626 serine palmitoyltransferase 1 cysteinylated 1 (human), hSPTLC1/Cyst:1

organism-modification


PR:000078051 serine palmitoyltransferase 1 methylated 1 (human), hSPTLC1/Me:1

organism-gene


PR:O35704 serine palmitoyltransferase 1 (mouse), mSPTLC1
Yes
Yes
organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse), mSPTLC1/iso:1
Yes
organism-gene


PR:O59682 serine palmitoyltransferase 1 (Schizosaccharomyces pombe 972h-), Spom972h-SPTLC1

organism-gene


PR:P25045 serine palmitoyltransferase 1 (yeast), ySPTLC1

organism-gene


PR:P91079 serine palmitoyltransferase 1 (worm), SPTLC1 (worm)

organism-gene


PR:Q55FL5 serine palmitoyltransferase 1 (Dictyostelium discoideum), Dicty-SPTLC1

organism-gene


PR:Q94IB8 long chain base biosynthesis protein 1 (Arabidopsis thaliana), At-SPTLC1

sequence


PR:000022019 serine palmitoyltransferase 1 isoform 1, SPTLC1/iso:1

organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human), hSPTLC1/iso:1

organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse), mSPTLC1/iso:1
Yes
gene


PR:000015597 serine palmitoyltransferase 2, SPTLC2

organism-gene


PR:O15270 serine palmitoyltransferase 2 (human), hSPTLC2

Yes
organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human), hSPTLC2/iso:1

organism-modification


PR:000049342 serine palmitoyltransferase 2 pyridoxal phosphate lysine 1 (human), hSPTLC2/Pyrdox:1

organism-modification


PR:000073274 serine palmitoyltransferase 2 methylated 1 (human), hSPTLC2/Me:1

organism-modification


PR:000083083 serine palmitoyltransferase 2 methylated 2 (human), hSPTLC2/Me:2

organism-gene


PR:P97363 serine palmitoyltransferase 2 (mouse), mSPTLC2
Yes
Yes
organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse), mSPTLC2/iso:1
Yes
organism-gene


PR:Q3B7D2 serine palmitoyltransferase 2 (rat), rSPTLC2

sequence


PR:000022020 serine palmitoyltransferase 2 isoform 1, SPTLC2/iso:1

organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human), hSPTLC2/iso:1

organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse), mSPTLC2/iso:1
Yes
gene


PR:000015598 serine palmitoyltransferase 3, SPTLC3

organism-gene


PR:Q8BG54 serine palmitoyltransferase 3 (mouse), mSPTLC3

Yes
organism-gene


PR:Q9NUV7 serine palmitoyltransferase 3 (human), hSPTLC3

Yes
organism-sequence


PR:Q9NUV7-1 serine palmitoyltransferase 3 isoform h1 (human), hSPTLC3/iso:h1

organism-sequence


PR:Q9NUV7-2 serine palmitoyltransferase 3 isoform h2 (human), hSPTLC3/iso:h2

organism-modification


PR:000049343 serine palmitoyltransferase 3 pyridoxal phosphate lysine 1 (human), hSPTLC3/Pyrdox:1

Back to top
fam:euk-SPT forms found in complexes   

fam:euk-SPT Component
 Complexes
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q8BG54 mSPTLC3 PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q9NUV7 hSPTLC3 PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:O35704 mSPTLC1
Lcb1 | Sptlc1 | LCB 1 (mouse) | long chain base biosynthesis protein 1 (mouse) | serine-palmitoyl-CoA transferase 1 (mouse) | SPT 1 (mouse) | SPT1 (mouse)
"A serine palmitoyltransferase 1 that is encoded in the genome of mouse." [OMA:O35704, PRO:HJD]		 acts_upstream_of_or_withinGO:0006686 sphingomyelin biosynthetic process PMID:16216550
GO:0046511 sphinganine biosynthetic process PMID:19416652
GO:0046512 sphingosine biosynthetic process PMID:16216550
GO:0046513 ceramide biosynthetic process PMID:16216550
PR:O35704-1 mSPTLC1/iso:1

"A serine palmitoyltransferase 1 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]		 enablesNOT GO:0004758 serine C-palmitoyltransferase activity PMID:9363775
GO:0005515 protein binding PMID:18484747
PR:P97363 mSPTLC2
Lcb2 | Sptlc2 | LCB 2 (mouse) | LCB2a (mouse) | long chain base biosynthesis protein 2 (mouse) | long chain base biosynthesis protein 2a (mouse) | serine-palmitoyl-CoA transferase 2 (mouse) | SPT 2 (mouse)
"A serine palmitoyltransferase 2 that is encoded in the genome of mouse." [OMA:P97363, PRO:HJD]		 acts_upstream_of_or_withinGO:0006686 sphingomyelin biosynthetic process PMID:16216550
GO:0046512 sphingosine biosynthetic process PMID:16216550
GO:0046513 ceramide biosynthetic process PMID:16216550
PR:P97363-1 mSPTLC2/iso:1

"A serine palmitoyltransferase 2 isoform 1 that is encoded in the genome of mouse." [PRO:HJD]		 acts_upstream_of_or_withinGO:0046511 sphinganine biosynthetic process PMID:9363775
enablesGO:0004758 serine C-palmitoyltransferase activity PMID:9363775
located_inGO:0005739 mitochondrion PMID:18614015