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Protein Ontology report - cellular tumor antigen p53 isoform 1 dimethylated 1
PR:000027765 -
http://purl.obolibrary.org/obo/PR_000027765
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027765
PRO name
cellular tumor antigen p53 isoform 1 dimethylated 1
Synonyms
PRO-Short-label
:
EXACT:
TP53/iso:1/Me2:1
Definition
"A cellular tumor antigen p53 isoform 1 that has been dimethylated on a Lys residue present in the [KR]Kx(2)[LF]K[TR] sequence within the C-terminal regulatory region. This modification may promote p53 stability in response to DNA damage signals. Example:
UniProtKB:P04637-1
, Lys-382,
MOD:00084
." [
PMID:18840612
, PRO:PD]
PRO Category
modification
Parent
PR:000003036
cellular tumor antigen p53 isoform 1
PR:000037074
methylated protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027765
cellular tumor antigen p53 isoform 1 dimethylated 1, TP53/iso:1/Me2:1
organism-modification
PR:000027766
cellular tumor antigen p53 isoform 1 dimethylated 1 (human), hTP53/iso:1/Me2:1
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027766
hTP53/iso:1/Me2:1
UniProtKB:P04637-1, Lys-382, MOD:00084 | p53K382me2
"A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]
enables
GO:0005515
protein binding
with
PR:Q12888
53BP1 (human)
PMID:18840612
