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Protein Ontology report - forkhead box protein O1 isoform 1 phosphorylated 1
PR:000027893 -
http://purl.obolibrary.org/obo/PR_000027893
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000027893
PRO name
forkhead box protein O1 isoform 1 phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
FOXO1/iso:1/Phos:1
Definition
"A forkhead box protein O1 isoform 1 that has been modified on a conserved Ser residue in the GKSPRRR motif at the C-terminus of the Forkhead box DNA-binding domain.This modification promotes FOXO1 activation and cell death in neurons. Example:
UniProtKB:Q12778
, Ser-249,
MOD:00046
." [
PMID:18356527
, PRO:PD]
PRO Category
modification
Parent
PR:000027868
forkhead box protein O1 isoform 1
PR:000037070
phosphoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000027893
forkhead box protein O1 isoform 1 phosphorylated 1, FOXO1/iso:1/Phos:1
organism-modification
PR:000027894
forkhead box protein O1 isoform 1 phosphorylated 1 (human), hFOXO1/iso:1/Phos:1
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000027894
hFOXO1/iso:1/Phos:1
UniProtKB:Q12778-1, Ser-249, MOD:00046 | FOXO1-pSer249
"A forkhead box protein O1 isoform 1 phosphorylated 1 in human. UniProtKB:Q12778-1, Ser-249, MOD:00046." [PMID:18356527, PRO:PD]
acts_upstream_of_or_within
GO:0010628
positive regulation of gene expression
PMID:18356527
enables
NOT
GO:0071889
14-3-3 protein binding
PMID:18356527
located_in
GO:0005634
nucleus
PMID:18356527
