Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - aurora kinase

PR:000035365 - http://purl.obolibrary.org/obo/PR_000035365

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000035365

PRO name

aurora kinase

Synonyms

Other:

EXACT:

AURK

Definition

"A protein that is a serine-threonine protein kinase that controls several aspects of cell division. It contains a copy of the Protein kinase domain (Pfam:PF00069)." [PIRSF:PIRSF501130, PMID:18662747, PRO:CNA]

PRO Category

family

Parent

PR:000000001

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Family	1	Organism-Family	0
Gene	4	Organism-Gene	18
Sequence	0	Organism-Sequence	10
Modification	3	Organism-Modification	10

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Related Cross References
Db identifiers	PIRSF:PIRSF501130

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

family

PR:000035365 aurora kinase, hCENPA/InitMet-/Phos:1

gene

PR:000004515 aurora kinase A, AURKA

organism-gene

PR:O14965 aurora kinase A (human), hAURKA

Yes

organism-modification

PR:000045573 aurora kinase A phosphorylated 1 (human), hAURKA/Phos:1

organism-modification

PR:000046439 aurora kinase A sumoylated 1 (human), hAURKA/Sumo:1

organism-modification

PR:000064814 aurora kinase A ubiquitinated form (human), hAURKA/UbiqLys+

organism-modification

PR:000084713 aurora kinase A hydroxylated 1 (human), hAURKA/Hy:1

organism-gene

PR:P59241 aurora kinase A (rat), rAURKA

organism-gene

PR:P97477 aurora kinase A (mouse), mAURKA

organism-sequence

PR:P97477-1 aurora kinase A isoform m1 (mouse), mAURKA/iso:m1

organism-sequence

PR:P97477-2 aurora kinase A isoform m2 (mouse), mAURKA/iso:m2

gene

PR:000004517 aurora kinase B, AURKB

organism-gene

PR:000060242 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe), Spom-AURKB

organism-gene

PR:O01427 aurora/IPL1-related protein kinase 2 (worm), AURKB (worm)

organism-gene

PR:O55099 aurora kinase B (rat), rAURKB

organism-gene

PR:O59790 serine/threonine-protein kinase ark1 (Schizosaccharomyces pombe 972h-), Spom972h-AURKB

organism-gene

PR:O70126 aurora kinase B (mouse), mAURKB

organism-gene

PR:Q6DE08 aurora kinase B-A (frog), frog-AURKB

organism-gene

PR:Q6NW76 aurora kinase B (zebrafish), z-AURKB

organism-gene

PR:Q96GD4 aurora kinase B (human), hAURKB

Yes

organism-sequence

PR:Q96GD4-1 aurora kinase B isoform h1 (human), hAURKB/iso:h1

organism-sequence

PR:Q96GD4-2 aurora kinase B isoform h2 (human), hAURKB/iso:h2

organism-sequence

PR:Q96GD4-3 aurora kinase B isoform h3 (human), hAURKB/iso:h3

organism-sequence

PR:Q96GD4-4 aurora kinase B isoform h4 (human), hAURKB/iso:h4

organism-sequence

PR:Q96GD4-5 aurora kinase B isoform h5 (human), hAURKB/iso:h5

organism-modification

PR:000035661 aurora kinase B unphosphorylated form (human), hAURKB/PhosRes-

Yes

organism-modification

PR:000035663 aurora kinase B phosphorylated 1 (human), hAURKB/Phos:1

Yes

organism-modification

PR:000046026 aurora kinase B phosphorylated 2 (human), hAURKB/Phos:2

organism-modification

PR:000046440 aurora kinase B sumoylated 1 (human), hAURKB/Sumo:1

organism-modification

PR:000075980 aurora kinase B methylated 1 (human), hAURKB/Me:1

organism-modification

PR:000077527 aurora kinase B cysteinylated 1 (human), hAURKB/Cyst:1

organism-gene

PR:Q9VKN7 aurora kinase B (fruit fly), fly-AURKB

modification

PR:000019090 aurora kinase B, initiator methionine removed form, AURKB/InitMet-

modification

PR:000035660 aurora kinase B unphosphorylated form, AURKB/PhosRes-

organism-modification

PR:000035661 aurora kinase B unphosphorylated form (human), hAURKB/PhosRes-

Yes

modification

PR:000035662 aurora kinase B phosphorylated 1, AURKB/Phos:1

organism-modification

PR:000035663 aurora kinase B phosphorylated 1 (human), hAURKB/Phos:1

Yes

gene

PR:000004518 aurora kinase C, AURKC

organism-gene

PR:D4AD76 aurora kinase C (rat), rAURKC

organism-gene

PR:O64629 serine/threonine-protein kinase Aurora-3 (Arabidopsis thaliana), At-AURKC

organism-gene

PR:O88445 aurora kinase C (mouse), mAURKC

organism-gene

PR:Q9UQB9 aurora kinase C (human), hAURKC

organism-sequence

PR:Q9UQB9-1 aurora kinase C isoform h1 (human), hAURKC/iso:h1

organism-sequence

PR:Q9UQB9-2 aurora kinase C isoform h2 (human), hAURKC/iso:h2

organism-sequence

PR:Q9UQB9-3 aurora kinase C isoform h3 (human), hAURKC/iso:h3

gene

PR:000029237 spindle assembly checkpoint kinase, IPL1

organism-gene

PR:P38991 spindle assembly checkpoint kinase (yeast), yIPL1

Yes

organism-gene

PR:Q54WX4 aurora kinase (Dictyostelium discoideum), Dicty-IPL1

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000035661 hAURKB/PhosRes-	enables	GO:0005515 protein binding with PR:Q9NQS7 hINCENP	PMID:22024163
PR:000035661 hAURKB/PhosRes-	located_in	GO:0000776 kinetochore	PMID:22024163
PR:000035663 hAURKB/Phos:1 UniProtKB:Q96GD4, Ser-331, MOD:00046 \| hAURKB active form	acts_upstream_of_or_within	increased GO:0007059 chromosome segregation relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
		increased GO:0031577 spindle checkpoint signaling relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
		increased GO:0051310 metaphase chromosome alignment relative to PR:000035661 hAURKB/PhosRes-	PMID:22024163
	enables	increased GO:0004672 protein kinase activity relative to PR:000035661 hAURKB/PhosRes-	PMID:17276342; PMID:22024163
	enables	GO:0005515 protein binding	PMID:22024163
	located_in	GO:0000776 kinetochore	PMID:22024163
PR:O14965 hAURKA AIK \| AIRK1 \| ARK1 \| AURA \| AURKA \| AYK1 \| BTAK \| IAK1 \| STK15 \| STK6 \| ARK-1 (human) \| aurora 2 (human) \| aurora-related kinase 1 (human) \| aurora/IPL1-related kinase 1 (human) \| breast tumor-amplified kinase (human) \| Ipl1- and aurora-related kinase 1 (human) \| serine/threonine-protein kinase 15 (human) \| serine/threonine-protein kinase 6 (human) \| serine/threonine-protein kinase aurora-A (human) \| serine/threonine-protein kinase Ayk1 (human)	enables	GO:0005515 protein binding with PR:Q9H4B4 CNK	PMID:15190214
	located_in	GO:0000922 spindle pole	PMID:15190214
		GO:0005813 centrosome	PMID:15190214
		GO:0030496 midbody	PMID:15190214
PR:P38991 yIPL1 IPL1 \| YPL209C \| aurora kinase (yeast) \| increase-in-ploidy protein 1 (yeast)	enables	GO:0004672 protein kinase activity	PMID:17504936
PR:Q96GD4 hAURKB AIK2 \| AIM1 \| AIRK2 \| ARK2 \| AURKB \| STK1 \| STK12 \| STK5 \| AIM-1 (human) \| ARK-2 (human) \| aurora 1 (human) \| aurora- and IPL1-like midbody-associated protein 1 (human) \| aurora-related kinase 2 (human) \| aurora/IPL1-related kinase 2 (human) \| serine/threonine-protein kinase 12 (human) \| serine/threonine-protein kinase 5 (human) \| serine/threonine-protein kinase aurora-B (human) \| STK-1 (human) (BROAD)	acts_upstream_of_or_within	GO:0007059 chromosome segregation	PMID:12719470
		GO:0008608 attachment of spindle microtubules to kinetochore	PMID:12719470; PMID:15592459
		GO:0031577 spindle checkpoint signaling	PMID:12719470
		GO:0034501 protein localization to kinetochore	PMID:12719470; PMID:17617734; PMID:22732840
		NOT GO:0051306 mitotic sister chromatid separation	PMID:12719470
		GO:0051310 metaphase chromosome alignment	PMID:12719470; PMID:22732840
		GO:0071459 protein localization to chromosome, centromeric region	PMID:12719470; PMID:21658950
		GO:0140014 mitotic nuclear division	PMID:12719470
	enables	GO:0004672 protein kinase activity	PMID:12719470
		GO:0005515 protein binding with PR:O60566 BUB1B	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:P06493 CDC2	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:P68431 H3C1	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q12834 CDC20	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q13043 hSTK4	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q15208 hSTK38	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q53HL2 CDCA8	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q71DI3 H3-clustered histone 13 (human)	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding with PR:Q9NQS7 hINCENP	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
		GO:0005515 protein binding	BioGRID:BG-251075; IntAct:EBI-1555366; MINT:MINT-77928
	located_in	GO:0000776 kinetochore	PMID:20624902
		GO:0000779 condensed chromosome, centromeric region	PMID:12719470; PMID:15917996
		GO:0000939 inner kinetochore	PMID:15592459
		GO:0030496 midbody	PMID:15917996
		GO:0051233 spindle midzone	PMID:15917996