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Protein Ontology report - dengue virus genome polyprotein proteolytic cleavage product
PR:000036818 - http://purl.obolibrary.org/obo/PR_000036818
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000036818   
  PRO namedengue virus genome polyprotein proteolytic cleavage product 
  Synonyms
PRO-Short-label: EXACT:DenV-polyprot/ClvPrd
  Definition"A dengue virus genome polyprotein, N-glycosylated form that has been processed by proteolytic cleavage." [PRO:DAN, PRO:ES] 
  CommentRequested by=IDODEN. 
  PRO Categorymodification 
  ParentPR:000018264
PR:000036817
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification28                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000036818 dengue virus genome polyprotein proteolytic cleavage product, DenV-polyprot/ClvPrd

modification


PR:000036819 capsid protein C, DenV-C

modification


PR:000036820 pr protein, DenV-pr

modification


PR:000036821 M protein, DenV-M

organism-modification


PR:000044757 M protein (Dengue virus 2 Thailand/16681/84), M (DEN26)
Yes
modification


PR:000036822 E protein, DenV-E

Yes
modification


PR:000036824 NS1, DenV-NS1

Yes
modification


PR:000037000 NS1, with complex sugar attached, DenV-NS1/sugar(+)

Yes
modification


PR:000037001 NS1, without complex sugar attached, DenV-NS1/sugar(-)

Yes
organism-modification


PR:000044758 NS1 (Dengue virus 2 Thailand/NGS-C/1944), NS1 (DEN2N)
Yes
modification


PR:000036825 NS2A, DenV-NS2A

organism-modification


PR:000044759 NS2A (Dengue virus 2 Thailand/NGS-C/1944), NS2A (DEN2N)
Yes
organism-modification


PR:000044760 NS2A (Dengue virus 2 Thailand/16681/84), NS2A (DEN26)
Yes
modification


PR:000036826 NS2A-alpha, DenV-NS2Aalpha

modification


PR:000036827 NS2B, DenV-NS2B

Yes
organism-modification


PR:000044761 NS2B (Dengue virus 2 Thailand/NGS-C/1944), NS2B (DEN2N)
Yes
modification


PR:000036828 NS3, DenV-NS3

Yes
organism-modification


PR:000044762 NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)
Yes
modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036832 precursor of NS4B, DenV-preNS4B

modification


PR:000036833 NS4B, DenV-NS4B

organism-modification


PR:000044766 NS4B (Dengue virus 2 Thailand/NGS-C/1944), NS4B (DEN2N)
Yes
organism-modification


PR:000044767 NS4B (Dengue virus 2 Thailand/16681/84), NS4B (DEN26)
Yes
modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036833 NS4B, DenV-NS4B

organism-modification


PR:000044766 NS4B (Dengue virus 2 Thailand/NGS-C/1944), NS4B (DEN2N)
Yes
organism-modification


PR:000044767 NS4B (Dengue virus 2 Thailand/16681/84), NS4B (DEN26)
Yes
modification


PR:000036834 precursor of NS5, DenV-preNS5

modification


PR:000036835 NS5, DenV-NS5

organism-modification


PR:000044768 NS5 (Dengue virus 2 Thailand/NGS-C/1944), NS5 (DEN2N)
Yes
modification


PR:000036840 NS4A-NS4B-NS5, DenV-NS4AB5

modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036835 NS5, DenV-NS5

organism-modification


PR:000044768 NS5 (Dengue virus 2 Thailand/NGS-C/1944), NS5 (DEN2N)
Yes
modification


PR:000036836 C-prM, DenV-CprM

modification


PR:000036819 capsid protein C, DenV-C

modification


PR:000036837 prM, DenV-prM

Yes
modification


PR:000036820 pr protein, DenV-pr

modification


PR:000036821 M protein, DenV-M

organism-modification


PR:000044757 M protein (Dengue virus 2 Thailand/16681/84), M (DEN26)
Yes
organism-modification


PR:000044769 prM (Dengue virus 2 Thailand/16681/84), prM (DEN26)
Yes
organism-modification


PR:000044770 prM (Dengue virus 2 Thailand/NGS-C/1944), prM (DEN2N)
Yes
modification


PR:000036837 prM, DenV-prM

Yes
modification


PR:000036820 pr protein, DenV-pr

modification


PR:000036821 M protein, DenV-M

organism-modification


PR:000044757 M protein (Dengue virus 2 Thailand/16681/84), M (DEN26)
Yes
organism-modification


PR:000044769 prM (Dengue virus 2 Thailand/16681/84), prM (DEN26)
Yes
organism-modification


PR:000044770 prM (Dengue virus 2 Thailand/NGS-C/1944), prM (DEN2N)
Yes
modification


PR:000036838 NS12345, DenV-NS12345

modification


PR:000036826 NS2A-alpha, DenV-NS2Aalpha

modification


PR:000036827 NS2B, DenV-NS2B

Yes
organism-modification


PR:000044761 NS2B (Dengue virus 2 Thailand/NGS-C/1944), NS2B (DEN2N)
Yes
modification


PR:000036839 NS345, DenV-NS345

modification


PR:000036828 NS3, DenV-NS3

Yes
organism-modification


PR:000044762 NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)
Yes
modification


PR:000036840 NS4A-NS4B-NS5, DenV-NS4AB5

modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036873 NS2B-NS3 polyprotein precursor, DenV-NS2B3

modification


PR:000036998 NS1-NS2A, DenV-NS12A

modification


PR:000036824 NS1, DenV-NS1

Yes
modification


PR:000037000 NS1, with complex sugar attached, DenV-NS1/sugar(+)

Yes
modification


PR:000037001 NS1, without complex sugar attached, DenV-NS1/sugar(-)

Yes
organism-modification


PR:000044758 NS1 (Dengue virus 2 Thailand/NGS-C/1944), NS1 (DEN2N)
Yes
modification


PR:000036825 NS2A, DenV-NS2A

organism-modification


PR:000044759 NS2A (Dengue virus 2 Thailand/NGS-C/1944), NS2A (DEN2N)
Yes
organism-modification


PR:000044760 NS2A (Dengue virus 2 Thailand/16681/84), NS2A (DEN26)
Yes
modification


PR:000036839 NS345, DenV-NS345

modification


PR:000036828 NS3, DenV-NS3

Yes
organism-modification


PR:000044762 NS3 (Dengue virus 2 Thailand/NGS-C/1944), NS3 (DEN2N)
Yes
modification


PR:000036840 NS4A-NS4B-NS5, DenV-NS4AB5

modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036840 NS4A-NS4B-NS5, DenV-NS4AB5

modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036841 NS4AB, DenV-NS4AB

modification


PR:000036830 NS4A, DenV-NS4A

organism-modification


PR:000044763 NS4A (Dengue virus 2 Thailand/NGS-C/1944), NS4A (DEN2N)
Yes
organism-modification


PR:000044764 NS4A (Dengue virus 2 Thailand/16681/84), NS4A (DEN26)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036842 2KNS4B, DenV-2KNS4B

modification


PR:000036831 2K, DenV-2K

organism-modification


PR:000044765 2K (Dengue virus 2 Thailand/NGS-C/1944), 2K (DEN2N)
Yes
modification


PR:000036843 NS4B-NS5, DenV-NS4B5

modification


PR:000036873 NS2B-NS3 polyprotein precursor, DenV-NS2B3

modification


PR:000036998 NS1-NS2A, DenV-NS12A

modification


PR:000036824 NS1, DenV-NS1

Yes
modification


PR:000037000 NS1, with complex sugar attached, DenV-NS1/sugar(+)

Yes
modification


PR:000037001 NS1, without complex sugar attached, DenV-NS1/sugar(-)

Yes
organism-modification


PR:000044758 NS1 (Dengue virus 2 Thailand/NGS-C/1944), NS1 (DEN2N)
Yes
modification


PR:000036825 NS2A, DenV-NS2A

organism-modification


PR:000044759 NS2A (Dengue virus 2 Thailand/NGS-C/1944), NS2A (DEN2N)
Yes
organism-modification


PR:000044760 NS2A (Dengue virus 2 Thailand/16681/84), NS2A (DEN26)
Yes
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DenV-polyprot/ClvPrd forms found in complexes   

DenV-polyprot/ClvPrd Component
 Complexes
PR:000036822 DenV-E PR:000036823^P000036999
PR:000036824 DenV-NS1 PR:000037002
PR:000036827 DenV-NS2B PR:000036829
PR:000036828 DenV-NS3 PR:000036829
PR:000036837 DenV-prM PR:000036823
PR:000037000 DenV-NS1/sugar(+) PR:000037003^P000037005
PR:000037001 DenV-NS1/sugar(-) PR:000037004
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044757
M (DEN26)
UniProtKB:P29990, 206-280 | PRO_0000037927		 acts_upstream_of_or_withinGO:0006955 immune response PMID:14963133
located_inGO:0019031 viral envelope PMID:14963133
PR:000044758
NS1 (DEN2N)
UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160 | PRO_0000037962, Asn-905/Asn-982, MOD:00160		 acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:23408612
GO:0097281 immune complex formation PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044759
NS2A (DEN2N)
UniProtKB:P14340, 1128-1345 | PRO_0000037963		 acts_upstream_of_or_withinGO:0019068 virion assembly PMID:23408612
GO:0019076 viral release from host cell PMID:23408612
GO:0019079 viral genome replication PMID:23408612
located_inGO:0019034 viral replication complex PMID:23408612
PR:000044760
NS2A (DEN26)
UniProtKB:P29990, 1128-1345 | PRO_0000037930		 acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044761
NS2B (DEN2N)
UniProtKB:P14340, 1346-1475 | PRO_0000037964		 acts_upstream_of_or_withinGO:1900005 positive regulation of serine-type endopeptidase activity PMID:10744671
enablescontributes_to GO:0008236 serine-type peptidase activity PMID:10744671
PR:000044762
NS3 (DEN2N)
UniProtKB:P14340, 1476-2093 | PRO_0000037965		 acts_upstream_of_or_withinGO:0019082 viral protein processing PMID:10744671
enablesGO:0003724 RNA helicase activity PMID:10744671
GO:0008236 serine-type peptidase activity PMID:10744671
GO:0017111 ribonucleoside triphosphate phosphatase activity PMID:10744671
PR:000044763
NS4A (DEN2N)
UniProtKB:P14340, 2094-2220 | PRO_0000037966		 acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:17276984
located_inGO:0019034 viral replication complex PMID:17276984
PR:000044764
NS4A (DEN26)
UniProtKB:P29990, 2094-2220 | PRO_0000037933		 acts_upstream_of_or_withinGO:0060339 negative regulation of type I interferon-mediated signaling pathway PMID:14612562
PR:000044765
2K (DEN2N)
UniProtKB:P14340, 2221-2243 | PRO_0000261391		 acts_upstream_of_or_withinGO:0045051 protein insertion into ER membrane by internal uncleaved signal-anchor sequence PMID:17276984
enablesGO:0043495 protein-membrane adaptor activity PMID:21810535
located_inGO:0016020 membrane PMID:21810535
PR:000044766
NS4B (DEN2N)
UniProtKB:P14340, 2244-2491 | PRO_0000037967		 acts_upstream_of_or_withinGO:0019079 viral genome replication PMID:21810535
located_inGO:0019034 viral replication complex PMID:21810535
PR:000044767
NS4B (DEN26)
UniProtKB:P29990, 2244-2491 | PRO_0000037934		 acts_upstream_of_or_withinGO:0039563 disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity PMID:14612562
PR:000044768
NS5 (DEN2N)
UniProtKB:P14340, 2492-3391 | PRO_0000037968		 acts_upstream_of_or_withinGO:0001510 RNA methylation PMID:21810535
GO:0019079 viral genome replication PMID:21810535
GO:0042783 evasion of host immune response PMID:21810535
enablesGO:0003968 RNA-dependent RNA polymerase activity PMID:21810535
GO:0008168 methyltransferase activity PMID:21810535
GO:0070568 guanylyltransferase activity PMID:23408612
located_inGO:0019034 viral replication complex PMID:21810535
PR:000044769
prM (DEN26)
UniProtKB:P29990, 115-280, Asn-183, MOD:00160 | PRO_0000264673, Asn-183, MOD:00160		 acts_upstream_of_or_withinGO:0015031 protein transport PMID:14963133
GO:0019068 virion assembly PMID:14963133
enablesGO:0044183 protein folding chaperone PMID:14963133
PR:000044770
prM (DEN2N)
UniProtKB:P14340, 115-280, Asn-183, MOD:00160 | PRO_0000261389, Asn-183, MOD:00160		 acts_upstream_of_or_withinGO:0006955 immune response PMID:8429301
located_inGO:0019031 viral envelope PMID:8429301