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PRO ID
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| PRO name | E protein |
| Synonyms | | PRO-Short-label: | EXACT: | DenV-E | | Other: | EXACT: | Envelope protein E |
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| Definition | "A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160." [PMID:17459925, PMID:23300717, PRO:DAN, PRO:ES] |
| Comment | Requested by=IDODEN. The E protein is responsible for eliciting the majority of the protective dengue virus antibody response. It covers the virion surface arranged in anti-parallel dimers containing three structural and antigenic domains [PMID:22709350, PRO:ES]. |
| PRO Category | modification |
| Parent | PR:000036818 dengue virus genome polyprotein proteolytic cleavage product
PR:000036817 dengue virus genome polyprotein, N-glycosylated form
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