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Protein Ontology report - viral dsRNA:TLR3 complex
PR:000037302 - http://purl.obolibrary.org/obo/PR_000037302
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000037302   
  PRO nameviral dsRNA:TLR3 complex 
  Synonyms
PRO-Short-label: EXACT:(vir)dsRNA:TLR3
  Definition"A macromolecular complex that is composed of viral double stranded RNA (dsRNA) and a homodimer of TLR3. Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA." [PMID:18420935, PMID:20861016, PRO:CNA, PRO:DAN, Reactome:R-HSA-167985] 
  CommentRequested by=TLR. 
  PRO Categorycomplex 
  ParentG0032991
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Complex1                                                  Organism-Complex 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
complex


PR:000037302 viral dsRNA:TLR3 complex, (vir)dsRNA:TLR3

organism-complex


PR:000037303 viral dsRNA:TLR3 complex (human), h(vir)dsRNA:TLR3
Yes
organism-complex


PR:000037304 viral dsRNA:TLR3 complex (mouse), h(vir)dsRNA:TLR3
Yes
organism-complex


PR:000037461 viral dsRNA:TLR3 complex (chicken), RET/iso:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037303
h(vir)dsRNA:TLR3
 acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
located_inGO:0010008 endosome membrane Reactome:REACT_6783
PR:000037304
h(vir)dsRNA:TLR3
 acts_upstream_of_or_withinGO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18420935
GO:0034138 toll-like receptor 3 signaling pathway PMID:18420935
PR:000037461
RET/iso:2
 acts_upstream_of_or_withinGO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_24923
located_inGO:0010008 endosome membrane Reactome:REACT_24923