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Protein Ontology report - chloride channel protein
PR:000044678 - http://purl.obolibrary.org/obo/PR_000044678
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000044678   
  PRO namechloride channel protein 
  Synonyms
PRO-Short-label: EXACT:fam:Cl_chan
  Definition"An ion channel protein that has chloride channel activity. A chloride channel enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GO:0005254, PRO:XQ] 
  PRO Categoryfamily 
  ParentPR:000049983 ion channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family4                                                  Organism-Family 0                                        
         Gene11                                                  Organism-Gene 35                                        
         Sequence7                                                  Organism-Sequence 71                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARfam:120
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000044678 chloride channel protein, fam:Cl_chan

gene


PR:000001044 cystic fibrosis transmembrane conductance regulator, CFTR

organism-gene


PR:P13569 cystic fibrosis transmembrane conductance regulator (human), hCFTR

organism-sequence


PR:000063429 cystic fibrosis transmembrane conductance regulator sequence variant N1303K (human), hCFTR/var:N1303K

organism-sequence


PR:000063523 cystic fibrosis transmembrane conductance regulator sequence variant G551D (human), hCFTR/var:G551D

organism-sequence


PR:P13569-1 cystic fibrosis transmembrane conductance regulator isoform 1 (human), hCFTR/iso:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human), hCFTR/iso:1/NGlyco:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human), hCFTR/iso:1/Phos:1
Yes
organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human), hCFTR/iso:1/Phos:2

organism-sequence


PR:P13569-2 cystic fibrosis transmembrane conductance regulator isoform 2 (human), hCFTR/iso:2

organism-sequence


PR:P13569-3 cystic fibrosis transmembrane conductance regulator isoform 3 (human), hCFTR/iso:3
Yes
organism-modification


PR:000046699 cystic fibrosis transmembrane conductance regulator ubiquitinated form (human), hCFTR/UbiqLys+

organism-modification


PR:000079746 cystic fibrosis transmembrane conductance regulator phosphorylated 1 (human), hCFTR/Phos:1

organism-gene


PR:P26361 cystic fibrosis transmembrane conductance regulator (mouse), mCFTR

organism-sequence


PR:P26361-1 cystic fibrosis transmembrane conductance regulator isoform 1 (mouse), mCFTR/iso:1

organism-sequence


PR:P26361-2 cystic fibrosis transmembrane conductance regulator isoform m2 (mouse), mCFTR/iso:m2

organism-sequence


PR:P26361-3 cystic fibrosis transmembrane conductance regulator isoform m3 (mouse), mCFTR/iso:m3

organism-gene


PR:P34158 cystic fibrosis transmembrane conductance regulator (rat), rCFTR

organism-sequence


PR:P34158-1 cystic fibrosis transmembrane conductance regulator isoform 1 (rat), rCFTR/iso:1

organism-gene


PR:Q1LX78 cystic fibrosis transmembrane conductance regulator (zebrafish), z-CFTR

sequence


PR:000001045 cftr isoform 1, CFTR/iso:1

organism-sequence


PR:P13569-1 cystic fibrosis transmembrane conductance regulator isoform 1 (human), hCFTR/iso:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human), hCFTR/iso:1/NGlyco:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human), hCFTR/iso:1/Phos:1
Yes
organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human), hCFTR/iso:1/Phos:2

organism-sequence


PR:P26361-1 cystic fibrosis transmembrane conductance regulator isoform 1 (mouse), mCFTR/iso:1

organism-sequence


PR:P34158-1 cystic fibrosis transmembrane conductance regulator isoform 1 (rat), rCFTR/iso:1

modification


PR:000001048 cftr isoform 1 glycosylated form, CFTR/iso:1/GlycoRes+

modification


PR:000001049 cftr isoform 1 N-glycosylated 1, CFTR/iso:1/NGlyco:1

organism-modification


PR:000036593 cftr isoform 1 N-glycosylated 1 (human), hCFTR/iso:1/NGlyco:1

modification


PR:000001050 cftr isoform 1 phosphorylated form, CFTR/iso:1/PhosRes+

modification


PR:000001051 cftr isoform 1 phosphorylated 1, CFTR/iso:1/Phos:1

organism-modification


PR:000036594 cftr isoform 1 phosphorylated 1 (human), hCFTR/iso:1/Phos:1
Yes
modification


PR:000001052 cftr isoform 1 phosphorylated 2, CFTR/iso:1/Phos:2

organism-modification


PR:000036595 cftr isoform 1 phosphorylated 2 (human), hCFTR/iso:1/Phos:2

sequence


PR:000001046 cftr isoform 2, CFTR/iso:2

organism-sequence


PR:P13569-2 cystic fibrosis transmembrane conductance regulator isoform 2 (human), hCFTR/iso:2

sequence


PR:000001047 cftr isoform 3, CFTR/iso:3

organism-sequence


PR:P13569-3 cystic fibrosis transmembrane conductance regulator isoform 3 (human), hCFTR/iso:3
Yes
family


PR:000044677 volume regulated chloride channel, fam:chan

family


PR:000044673 CIC family protein, fam:CIC

gene


PR:000005528 chloride channel protein, skeletal muscle, CLCN1

organism-gene


PR:P35523 chloride channel protein 1 (human), hCLCN1

organism-gene


PR:P35524 chloride channel protein 1 (rat), rCLCN1

organism-sequence


PR:P35524-1 chloride channel protein 1 isoform 1 (rat), rCLCN1/iso:1

organism-gene


PR:Q54C67 chloride channel protein F (Dictyostelium discoideum), Dicty-CLCN1

organism-gene


PR:Q64347 chloride channel protein 1 (mouse), mCLCN1

organism-sequence


PR:Q64347-1 chloride channel protein 1 isoform 1 (mouse), mCLCN1/iso:1

sequence


PR:000041112 chloride channel protein, skeletal muscle isoform 1, CLCN1/iso:1

organism-sequence


PR:P35524-1 chloride channel protein 1 isoform 1 (rat), rCLCN1/iso:1

organism-sequence


PR:Q64347-1 chloride channel protein 1 isoform 1 (mouse), mCLCN1/iso:1

gene


PR:000005529 chloride channel protein 2, CLCN2

organism-gene


PR:P35525 chloride channel protein 2 (rat), rCLCN2

organism-gene


PR:P51788 chloride channel protein 2 (human), hCLCN2

organism-sequence


PR:P51788-1 chloride channel protein 2 isoform h1 (human), hCLCN2/iso:h1

organism-sequence


PR:P51788-2 chloride channel protein 2 isoform h2 (human), hCLCN2/iso:h2

organism-sequence


PR:P51788-3 chloride channel protein 2 isoform h3 (human), hCLCN2/iso:h3

organism-sequence


PR:P51788-4 chloride channel protein 2 isoform h4 (human), hCLCN2/iso:h4

organism-sequence


PR:P51788-5 chloride channel protein 2 isoform h5 (human), hCLCN2/iso:h5

organism-gene


PR:Q9R0A1 chloride channel protein 2 (mouse), mCLCN2

organism-gene


PR:Q9VGH7 chloride channel protein 2 (fruit fly), fly-CLCN2

organism-sequence


PR:Q9VGH7-1 chloride channel protein 2 isoform D (fruit fly), fly-CLCN2/iso:D

organism-sequence


PR:Q9VGH7-2 chloride channel protein 2 isoform A (fruit fly), fly-CLCN2/iso:A

organism-sequence


PR:Q9VGH7-3 chloride channel protein 2 isoform F (fruit fly), fly-CLCN2/iso:F

organism-sequence


PR:Q9VGH7-4 chloride channel protein 2 isoform C (fruit fly), fly-CLCN2/iso:C

organism-sequence


PR:Q9VGH7-6 chloride channel protein 2 isoform G (fruit fly), fly-CLCN2/iso:G

organism-sequence


PR:Q9VGH7-7 chloride channel protein 2 isoform H (fruit fly), fly-CLCN2/iso:H

gene


PR:000005530 H(+)/Cl(-) exchange transporter 3, CLCN3

organism-gene


PR:P51790 H(+)/Cl(-) exchange transporter 3 (human), hCLCN3

organism-sequence


PR:P51790-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (human), hCLCN3/iso:1

organism-sequence


PR:P51790-2 H(+)/Cl(-) exchange transporter 3 isoform h2 (human), hCLCN3/iso:h2

organism-sequence


PR:P51790-4 H(+)/Cl(-) exchange transporter 3 isoform h3 (human), hCLCN3/iso:h3

organism-sequence


PR:P51790-5 H(+)/Cl(-) exchange transporter 3 isoform h4 (human), hCLCN3/iso:h4

organism-modification


PR:000045819 H(+)/Cl(-) exchange transporter 3 phosphorylated 1 (human), hCLCN3/Phos:1

organism-gene


PR:P51791 H(+)/Cl(-) exchange transporter 3 (mouse), mCLCN3

organism-sequence


PR:P51791-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (mouse), mCLCN3/iso:1

organism-sequence


PR:P51791-2 H(+)/Cl(-) exchange transporter 3 isoform m2 (mouse), mCLCN3/iso:m2

organism-sequence


PR:P51791-3 H(+)/Cl(-) exchange transporter 3 isoform m3 (mouse), mCLCN3/iso:m3

organism-sequence


PR:P51791-4 H(+)/Cl(-) exchange transporter 3 isoform m4 (mouse), mCLCN3/iso:m4

organism-sequence


PR:P51791-5 H(+)/Cl(-) exchange transporter 3 isoform m5 (mouse), mCLCN3/iso:m5

organism-gene


PR:P51792 H(+)/Cl(-) exchange transporter 3 (rat), rCLCN3

organism-sequence


PR:P51792-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (rat), rCLCN3/iso:1

organism-sequence


PR:P51792-2 H(+)/Cl(-) exchange transporter 3 isoform r2 (rat), rCLCN3/iso:r2

sequence


PR:000039679 H(+)/Cl(-) exchange transporter 3 isoform 1, CLCN3/iso:1

organism-sequence


PR:P51790-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (human), hCLCN3/iso:1

organism-sequence


PR:P51791-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (mouse), mCLCN3/iso:1

organism-sequence


PR:P51792-1 H(+)/Cl(-) exchange transporter 3 isoform 1 (rat), rCLCN3/iso:1

gene


PR:000005531 H(+)/Cl(-) exchange transporter 4, CLCN4

organism-gene


PR:P51793 H(+)/Cl(-) exchange transporter 4 (human), hCLCN4

organism-sequence


PR:P51793-1 H(+)/Cl(-) exchange transporter 4 isoform h1 (human), hCLCN4/iso:h1

organism-sequence


PR:P51793-2 H(+)/Cl(-) exchange transporter 4 isoform h2 (human), hCLCN4/iso:h2

organism-gene


PR:P51794 H(+)/Cl(-) exchange transporter 4 (rat), rCLCN4

organism-gene


PR:Q61418 H(+)/Cl(-) exchange transporter 4 (mouse), mCLCN4

gene


PR:000005532 H(+)/Cl(-) exchange transporter 5, CLCN5

organism-gene


PR:P51795 H(+)/Cl(-) exchange transporter 5 (human), hCLCN5

organism-sequence


PR:P51795-1 H(+)/Cl(-) exchange transporter 5 isoform h2 (human), hCLCN5/iso:h2

organism-sequence


PR:P51795-2 H(+)/Cl(-) exchange transporter 5 isoform h1 (human), hCLCN5/iso:h1

organism-gene


PR:P51796 H(+)/Cl(-) exchange transporter 5 (rat), rCLCN5

organism-sequence


PR:P51796-1 H(+)/Cl(-) exchange transporter 5 isoform r1 (rat), rCLCN5/iso:r1

organism-sequence


PR:P51796-2 H(+)/Cl(-) exchange transporter 5 isoform r2 (rat), rCLCN5/iso:r2

organism-gene


PR:Q9WVD4 H(+)/Cl(-) exchange transporter 5 (mouse), mCLCN5

organism-sequence


PR:Q9WVD4-1 H(+)/Cl(-) exchange transporter 5 isoform m1 (mouse), mCLCN5/iso:m1

organism-sequence


PR:Q9WVD4-2 H(+)/Cl(-) exchange transporter 5 isoform m2 (mouse), mCLCN5/iso:m2

gene


PR:000005533 chloride channel protein 6, CLCN6

organism-gene


PR:O35454 H(+)/Cl(-) exchange transporter 6 (mouse), mCLCN6

organism-sequence


PR:O35454-1 H(+)/Cl(-) exchange transporter 6 isoform mClC-6a (mouse), mCLCN6/iso:mClC-6a

organism-sequence


PR:O35454-2 H(+)/Cl(-) exchange transporter 6 isoform mClC-6c (mouse), mCLCN6/iso:mClC-6c

organism-gene


PR:P51797 H(+)/Cl(-) exchange transporter 6 (human), hCLCN6

organism-sequence


PR:P51797-1 H(+)/Cl(-) exchange transporter 6 isoform h1 (human), hCLCN6/iso:h1

organism-sequence


PR:P51797-2 H(+)/Cl(-) exchange transporter 6 isoform h2 (human), hCLCN6/iso:h2

organism-sequence


PR:P51797-3 H(+)/Cl(-) exchange transporter 6 isoform h3 (human), hCLCN6/iso:h3

organism-sequence


PR:P51797-4 H(+)/Cl(-) exchange transporter 6 isoform h4 (human), hCLCN6/iso:h4

organism-sequence


PR:P51797-5 H(+)/Cl(-) exchange transporter 6 isoform h5 (human), hCLCN6/iso:h5

organism-sequence


PR:P51797-6 H(+)/Cl(-) exchange transporter 6 isoform h6 (human), hCLCN6/iso:h6

gene


PR:000005534 H(+)/Cl(-) exchange transporter 7, CLCN7

organism-gene


PR:O60159 putative anion/proton exchange transporter C19C7.11 (Schizosaccharomyces pombe 972h-), Spom972h-CLCN7

organism-gene


PR:O70496 H(+)/Cl(-) exchange transporter 7 (mouse), mCLCN7

organism-sequence


PR:O70496-1 H(+)/Cl(-) exchange transporter 7 isoform 1 (mouse), mCLCN7/iso:1

organism-gene


PR:P51798 H(+)/Cl(-) exchange transporter 7 (human), hCLCN7

organism-sequence


PR:P51798-1 H(+)/Cl(-) exchange transporter 7 isoform h1 (human), hCLCN7/iso:h1

organism-sequence


PR:P51798-2 H(+)/Cl(-) exchange transporter 7 isoform h2 (human), hCLCN7/iso:h2

organism-modification


PR:000067337 H(+)/Cl(-) exchange transporter 7 methylated 1 (human), hCLCN7/Me:1

organism-modification


PR:000080034 H(+)/Cl(-) exchange transporter 7 deaminated 1 (human), hCLCN7/Deam:1

organism-gene


PR:P51799 H(+)/Cl(-) exchange transporter 7 (rat), rCLCN7

organism-sequence


PR:P51799-1 H(+)/Cl(-) exchange transporter 7 isoform 1 (rat), rCLCN7/iso:1

sequence


PR:000038303 H(+)/Cl(-) exchange transporter 7 isoform 1, CLCN7/iso:1

organism-sequence


PR:O70496-1 H(+)/Cl(-) exchange transporter 7 isoform 1 (mouse), mCLCN7/iso:1

organism-sequence


PR:P51799-1 H(+)/Cl(-) exchange transporter 7 isoform 1 (rat), rCLCN7/iso:1

gene


PR:000005535 chloride channel protein ClC-Ka, CLCNKA

organism-gene


PR:P51800 chloride channel protein ClC-Ka (human), hCLCNKA

organism-sequence


PR:P51800-1 chloride channel protein ClC-Ka isoform 1 (human), hCLCNKA/iso:1

organism-sequence


PR:P51800-2 chloride channel protein ClC-Ka isoform h2 (human), hCLCNKA/iso:h2

organism-sequence


PR:P51800-3 chloride channel protein ClC-Ka isoform h3 (human), hCLCNKA/iso:h3

organism-gene


PR:Q06393 chloride channel protein ClC-Ka (rat), rCLCNKA

organism-sequence


PR:Q06393-1 chloride channel protein ClC-Ka isoform 1 (rat), rCLCNKA/iso:1

organism-gene


PR:Q9WUB7 chloride channel protein ClC-Ka (mouse), mCLCNKA

organism-sequence


PR:Q9WUB7-1 chloride channel protein ClC-Ka isoform 1 (mouse), mCLCNKA/iso:1

sequence


PR:000039680 chloride channel protein ClC-Ka isoform 1, CLCNKA/iso:1

organism-sequence


PR:P51800-1 chloride channel protein ClC-Ka isoform 1 (human), hCLCNKA/iso:1

organism-sequence


PR:Q06393-1 chloride channel protein ClC-Ka isoform 1 (rat), rCLCNKA/iso:1

organism-sequence


PR:Q9WUB7-1 chloride channel protein ClC-Ka isoform 1 (mouse), mCLCNKA/iso:1

gene


PR:000005536 chloride channel protein ClC-Kb, CLCNKB

organism-gene


PR:P51801 chloride channel protein ClC-Kb (human), hCLCNKB

organism-sequence


PR:P51801-1 chloride channel protein ClC-Kb isoform h1 (human), hCLCNKB/iso:h1

organism-sequence


PR:P51801-2 chloride channel protein ClC-Kb isoform h2 (human), hCLCNKB/iso:h2

organism-gene


PR:P51802 chloride channel protein ClC-Kb (rat), rCLCNKB

organism-sequence


PR:P51802-1 chloride channel protein ClC-Kb isoform r1 (rat), rCLCNKB/iso:r1

organism-sequence


PR:P51802-2 chloride channel protein ClC-Kb isoform r2 (rat), rCLCNKB/iso:r2

organism-gene


PR:Q9WUB6 chloride channel protein ClC-Kb (mouse), mCLCNKB

organism-sequence


PR:Q9WUB6-1 chloride channel protein ClC-Kb isoform m1 (mouse), mCLCNKB/iso:m1

organism-sequence


PR:Q9WUB6-2 chloride channel protein ClC-Kb isoform m2 (mouse), mCLCNKB/iso:m2

family


PR:000044675 calcium activated chloride channel protein, fam:Ca-activ_Cl_chan

gene


PR:000004055 anoctamin-1, ANO1

organism-gene


PR:Q5XXA6 anoctamin-1 (human), hANO1

organism-sequence


PR:Q5XXA6-1 anoctamin-1 isoform h1 (human), hANO1/iso:h1

organism-sequence


PR:Q5XXA6-2 anoctamin-1 isoform h2 (human), hANO1/iso:h2

organism-sequence


PR:Q5XXA6-3 anoctamin-1 isoform h3 (human), hANO1/iso:h3

organism-sequence


PR:Q5XXA6-4 anoctamin-1 isoform h4 (human), hANO1/iso:h4

organism-sequence


PR:Q5XXA6-5 anoctamin-1 isoform h5 (human), hANO1/iso:h5

organism-gene


PR:Q8BHY3 anoctamin-1 (mouse), mANO1

organism-sequence


PR:Q8BHY3-1 anoctamin-1 isoform m1 (mouse), mANO1/iso:m1

organism-sequence


PR:Q8BHY3-2 anoctamin-1 isoform m2 (mouse), mANO1/iso:m2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036594 hCFTR/iso:1/Phos:1
UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046
"A cftr isoform 1 phosphorylated 1 in human. Example: UniProtKB:P13569-1, Ser-737/Ser-768/Ser-795/Ser-813, MOD:00046." [PMID:1377674, PMID:14602047, PMID:1716180, PRO:CNA]		 enablesGO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180
GO:0005260 intracellularly ATP-gated chloride channel activity PMID:1716180
PR:P13569-3 hCFTR/iso:3

"A cftr isoform 3 that is encoded in the genome of human." [PRO:CNA]		 associated_with_disease_progressionDO:1485 cystic fibrosis PMID:12913074