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RACE-PRO
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Documentation
Protein Ontology report - left-right determination factor 2 (human)
PR:O00292 -
http://purl.obolibrary.org/obo/PR_O00292
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:O00292
PRO name
left-right determination factor 2 (human)
Synonyms
PRO-Short-label
:
EXACT:
hLEFTY2
Gene-based
:
RELATED:
EBAF | LEFTA | LEFTY2 | LEFTYA | PSEC0024 | TGFB4
Other
:
EXACT:
endometrial bleeding-associated factor (human) | left-right determination factor A (human) | protein lefty-2 (human) | protein lefty-A (human) | TGF-beta-4 (human) | transforming growth factor beta-4 (human)
Definition
"A lefty 2 that is encoded in the genome of human." [PRO:CNA,
UniProtKB:O00292
]
PRO Category
organism-gene
Parent
PR:000000288
lefty 2
PR:000029067
Homo sapiens protein
Gene Template
HGNC:3122
LEFTY2 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
0
Organism-Gene
1
Sequence
0
Organism-Sequence
3
Modification
0
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB:O00292
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
organism-gene
PR:O00292
left-right determination factor 2 (human), hLEFTY2
organism-sequence
PR:000000452
lefty 2 sequence variant S342N (human), hLEFTY2/var:S342N
Yes
organism-sequence
PR:O00292-1
left-right determination factor 2 isoform 1 (human), hLEFTY2/iso:1
Yes
organism-modification
PR:000036549
lefty 2 isoform 1 cleaved 1 (human), hLEFTY2/iso:1/Clv:1
Yes
organism-modification
PR:000036550
lefty 2 isoform 1 cleaved 2 (human), hLEFTY2/iso:1/Clv:2
Yes
organism-sequence
PR:O00292-2
left-right determination factor 2 isoform h2 (human), hLEFTY2/iso:h2
organism-modification
PR:000048185
left-right determination factor 2, signal peptide removed form (human), hLEFTY2/SigPep-
organism-modification
PR:000083292
left-right determination factor 2 phosphorylated 1 (human), hLEFTY2/Phos:1
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000452
hLEFTY2/var:S342N
UniProtKB:O00292, Ser-342, CHEBI:50347 | UniProtKB:O00292-1, Ser-342, CHEBI:50347 | lefty 2 sequence variant 1 (human)
"A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0050545
visceral heterotaxy
PMID:10053005
PR:000036549
hLEFTY2/iso:1/Clv:1
UniProtKB:O00292-1, 77-366 | PRO_0000033807
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
acts_upstream_of_or_within
GO:0007275
multicellular organism development
PMID:10053005
GO:0007309
oocyte axis specification
PMID:10053005
located_in
GO:0005615
extracellular space
PMID:11278322
PR:000036550
hLEFTY2/iso:1/Clv:2
UniProtKB:O00292-1, 135-366
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
acts_upstream_of_or_within
GO:0043406
positive regulation of MAP kinase activity
PMID:11278322
located_in
GO:0005615
extracellular space
PMID:11278322
PR:O00292-1
hLEFTY2/iso:1
"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0007275
multicellular organism development
PMID:10053005
GO:0007309
oocyte axis specification
PMID:10053005
