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Protein Ontology report - mothers against decapentaplegic homolog 3 (mouse)
PR:Q8BUN5 - http://purl.obolibrary.org/obo/PR_Q8BUN5
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q8BUN5   
  PRO namemothers against decapentaplegic homolog 3 (mouse) 
  Synonyms
PRO-Short-label: EXACT:mSMAD3
Gene-based: RELATED:Madh3 | Smad3
Other: EXACT:MAD homolog 3 (mouse) | mMad3 | mothers against DPP homolog 3 (mouse) | SMAD 3 (mouse) | SMAD family member 3 (mouse)
RELATED:Mad3 (mouse)
  Definition"A smad3 that is encoded in the genome of mouse." [OMA:Q8BUN5, PRO:DNx] 
  PRO Categoryorganism-gene 
  ParentPR:000000365
PR:000029032
  Gene TemplateMGI:1201674 Smad3 (mouse)
  TaxonNCBITaxon:10090 Mus musculus
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q8BUN5
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:Q8BUN5 mothers against decapentaplegic homolog 3 (mouse), mSMAD3

organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse), mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036558
mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046		 enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560
mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561
mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:Q8BUN5-1
mSMAD3/iso:1
 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
enablesGO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125