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Protein Ontology report - mitogen-activated protein kinase
PR:000000019 - http://purl.obolibrary.org/obo/PR_000000019
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000019   
  PRO namemitogen-activated protein kinase 
  Synonyms
Other: EXACT:MAPK
RELATED:kinase-related transforming protein
  Definition"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 8                                        
         Sequence2                                                  Organism-Sequence 11                                        
         Modification10                                                  Organism-Modification 26                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF501110
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000019 mitogen-activated protein kinase, IFNG
Yes
gene


PR:000000103 mitogen-activated protein kinase 1, MAPK1

organism-gene


PR:P28482 mitogen-activated protein kinase 1 (human), hMAPK1

organism-sequence


PR:P28482-1 mitogen-activated protein kinase 1 isoform 1 (human), hMAPK1/iso:1
Yes
organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human), hMAPK1/iso:1/Phos:1
Yes
organism-sequence


PR:P28482-2 mitogen-activated protein kinase 1 isoform h2 (human), hMAPK1/iso:h2

organism-modification


PR:000045734 mitogen-activated protein kinase 1 phosphorylated 1 (human), hMAPK1/Phos:1

organism-modification


PR:000048313 mitogen-activated protein kinase 1, initiator methionine removed form (human), hMAPK1/InitMet-

organism-modification


PR:000048314 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human), hMAPK1/InitMet-/Phos:1

organism-modification


PR:000060366 mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:D321V/InitMet-/Phos:1

organism-modification


PR:000060482 mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:E322K/InitMet-/Phos:1

organism-modification


PR:000061403 mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:P58G/InitMet-/Phos:1

organism-modification


PR:000061840 mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:E81K/InitMet-/Phos:1

organism-modification


PR:000062009 mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:E322V/InitMet-/Phos:1

organism-modification


PR:000062395 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human), hMAPK1/InitMet-/Phos:2

organism-modification


PR:000062794 mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:D321N/InitMet-/Phos:1

organism-modification


PR:000062965 mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:P58L/InitMet-/Phos:1

organism-modification


PR:000063285 mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:S142L/InitMet-/Phos:1

organism-modification


PR:000063321 mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human), hMAPK1/var:E322A/InitMet-/Phos:1

organism-modification


PR:000083225 mitogen-activated protein kinase 1 cysteinylated 1 (human), hMAPK1/Cyst:1

organism-modification


PR:000083581 mitogen-activated protein kinase 1 methylated 1 (human), hMAPK1/Me:1

organism-modification


PR:000084106 mitogen-activated protein kinase 1 methylated 2 (human), hMAPK1/Me:2

organism-gene


PR:P39745 mitogen-activated protein kinase mpk-1 (worm), MAPK1 (worm)

organism-sequence


PR:P39745-1 mitogen-activated protein kinase mpk-1 isoform b (worm), MAPK1/iso:b (worm)

organism-sequence


PR:P39745-2 mitogen-activated protein kinase mpk-1 isoform a (worm), MAPK1/iso:a (worm)

organism-gene


PR:P42525 extracellular signal-regulated kinase 1 (Dictyostelium discoideum), Dicty-MAPK1

organism-gene


PR:P63085 mitogen-activated protein kinase 1 (mouse), mMAPK1

organism-sequence


PR:P63085-1 mitogen-activated protein kinase 1 isoform 1 (mouse), mMAPK1/iso:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse), mMAPK1/iso:1/Phos:1
Yes
organism-gene


PR:P63086 mitogen-activated protein kinase 1 (rat), rMAPK1

organism-modification


PR:000036466 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat), rMAPK1/iso:1/Phos:1
Yes
sequence


PR:000000289 mitogen-activated protein kinase 1 isoform 1, MAPK1/iso:1

organism-sequence


PR:P28482-1 mitogen-activated protein kinase 1 isoform 1 (human), hMAPK1/iso:1
Yes
organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human), hMAPK1/iso:1/Phos:1
Yes
organism-sequence


PR:P63085-1 mitogen-activated protein kinase 1 isoform 1 (mouse), mMAPK1/iso:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse), mMAPK1/iso:1/Phos:1
Yes
modification


PR:000000454 mitogen-activated protein kinase 1 isoform 1 phosphorylated form, MAPK1/iso:1/PhosRes+

modification


PR:000000556 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1, MAPK1/iso:1/Phos:1

organism-modification


PR:000026341 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human), hMAPK1/iso:1/Phos:1
Yes
organism-modification


PR:000036464 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse), mMAPK1/iso:1/Phos:1
Yes
organism-modification


PR:000036466 mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat), rMAPK1/iso:1/Phos:1
Yes
modification


PR:000025465 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form, MAPK1/iso:1/InitMet-

modification


PR:000000453 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form, MAPK1/iso:1/InitMet-/AcRes+

modification


PR:000018278 mitogen-activated protein kinase 1, initiator methionine removed form, MAPK1/InitMet-

modification


PR:000025465 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form, MAPK1/iso:1/InitMet-

modification


PR:000000453 mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form, MAPK1/iso:1/InitMet-/AcRes+

organism-modification


PR:000048313 mitogen-activated protein kinase 1, initiator methionine removed form (human), hMAPK1/InitMet-

organism-modification


PR:000048314 mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human), hMAPK1/InitMet-/Phos:1

modification


PR:000025458 mitogen-activated protein kinase 1 proteolytic cleavage product, MAPK1/ClvPrd

gene


PR:000000104 mitogen-activated protein kinase 3, MAPK3

organism-gene


PR:P21708 mitogen-activated protein kinase 3 (rat), rMAPK3

organism-sequence


PR:P21708-1 mitogen-activated protein kinase 3 isoform r1 (rat), rMAPK3/iso:r1

organism-sequence


PR:P21708-2 mitogen-activated protein kinase 3 isoform r2 (rat), rMAPK3/iso:r2

organism-gene


PR:P27361 mitogen-activated protein kinase 3 (human), hMAPK3

organism-sequence


PR:P27361-1 mitogen-activated protein kinase 3 isoform 1 (human), hMAPK3/iso:1
Yes
organism-modification


PR:000026189 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human), hMAPK3/iso:1/Phos:1
Yes
organism-sequence


PR:P27361-2 mitogen-activated protein kinase 3 isoform h2 (human), hMAPK3/iso:h2

organism-sequence


PR:P27361-3 mitogen-activated protein kinase 3 isoform h3 (human), hMAPK3/iso:h3

organism-modification


PR:000063126 mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human), hMAPK3/iso:h3/InitMet-/Phos:1

organism-modification


PR:000048321 mitogen-activated protein kinase 3, initiator methionine removed form (human), hMAPK3/InitMet-

organism-modification


PR:000048322 mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human), hMAPK3/InitMet-/Phos:1

organism-modification


PR:000060765 mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 2 (human), hMAPK3/InitMet-/Phos:2

organism-modification


PR:000065834 mitogen-activated protein kinase 3 methylated 1 (human), hMAPK3/Me:1

organism-gene


PR:Q63844 mitogen-activated protein kinase 3 (mouse), mMAPK3

organism-sequence


PR:Q63844-1 mitogen-activated protein kinase 3 isoform 1 (mouse), mMAPK3/iso:1
Yes
organism-modification


PR:000036468 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse), mMAPK3/iso:1/Phos:1
Yes
sequence


PR:000000290 mitogen-activated protein kinase 3 isoform 1, MAPK3/iso:1

organism-sequence


PR:P27361-1 mitogen-activated protein kinase 3 isoform 1 (human), hMAPK3/iso:1
Yes
organism-modification


PR:000026189 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human), hMAPK3/iso:1/Phos:1
Yes
organism-sequence


PR:Q63844-1 mitogen-activated protein kinase 3 isoform 1 (mouse), mMAPK3/iso:1
Yes
organism-modification


PR:000036468 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse), mMAPK3/iso:1/Phos:1
Yes
modification


PR:000000455 mitogen-activated protein kinase 3 isoform 1 phosphorylated form, MAPK3/iso:1/PhosRes+

modification


PR:000000557 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1, MAPK3/iso:1/Phos:1

organism-modification


PR:000026189 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human), hMAPK3/iso:1/Phos:1
Yes
organism-modification


PR:000036468 mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse), mMAPK3/iso:1/Phos:1
Yes
modification


PR:000026627 mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form, MAPK3/iso:1/InitMet-

modification


PR:000018279 mitogen-activated protein kinase 3, initiator methionine removed form, MAPK3/InitMet-

modification


PR:000026627 mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form, MAPK3/iso:1/InitMet-

organism-modification


PR:000048321 mitogen-activated protein kinase 3, initiator methionine removed form (human), hMAPK3/InitMet-

organism-modification


PR:000048322 mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human), hMAPK3/InitMet-/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000019 IFNG
MAPK | kinase-related transforming protein
"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PIRSF:PIRSF501110
enablesGO:0004672 protein kinase activity PIRSF:PIRSF501110
PR:000026189 hMAPK3/iso:1/Phos:1
UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048 | activated ERK1 | activated MAPK3
"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:7687743
GO:0051726 regulation of cell cycle PMID:7687743
enablesGO:0004672 protein kinase activity PMID:16581800
PR:000026341 hMAPK1/iso:1/Phos:1
UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:10958679
GO:0006935 chemotaxis PMID:10706854
GO:0007165 signal transduction PMID:1540184
enablesGO:0004672 protein kinase activity PMID:10706854
GO:0004707 MAP kinase activity PMID:10706854
GO:0005515 protein binding PMID:16291755
PR:000036464 mMAPK1/iso:1/Phos:1
UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]		 acts_upstream_of_or_withinGO:0000165 MAPK cascade PMID:8626447
GO:0006468 protein phosphorylation PMID:15284227
GO:0007165 signal transduction PMID:11684667
enablesGO:0004672 protein kinase activity PMID:14744933
GO:0004707 MAP kinase activity PMID:11684667; PMID:12223545; PMID:15314156; PMID:8626447
located_inGO:0005634 nucleus PMID:11726647; PMID:12925581; PMID:16251435
PR:000036466 rMAPK1/iso:1/Phos:1
UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048
"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA]		 enablesGO:0042803 protein homodimerization activity PMID:9604935
PR:000036468 mMAPK3/iso:1/Phos:1
UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048
"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11841548; PMID:15383658
enablesGO:0004672 protein kinase activity PMID:11684667; PMID:15314156
GO:0004707 MAP kinase activity PMID:15314156
located_inGO:0005634 nucleus PMID:11726647
PR:P27361-1 hMAPK3/iso:1

"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:7687743
PR:P28482-1 hMAPK1/iso:1

"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006935 chemotaxis PMID:10706854
GO:0006950 response to stress PMID:10958679
GO:0007268 chemical synaptic transmission PMID:10706854
enablesNOT GO:0004707 MAP kinase activity PMID:10706854
PR:P63085-1 mMAPK1/iso:1

"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 located_inGO:0005737 cytoplasm PMID:11726647; PMID:12223545
PR:Q63844-1 mMAPK3/iso:1

"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 enablesGO:0005515 protein binding with PR:Q9DAJ4 MAPK organizer 1 (mouse) PMID:15118098
located_inGO:0005737 cytoplasm PMID:11726647; PMID:12223545