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Protein Ontology report - TGF-beta receptor-regulated smad protein
PR:000000066 - http://purl.obolibrary.org/obo/PR_000000066
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000066   
  PRO nameTGF-beta receptor-regulated smad protein 
  Synonyms
PRO-Short-label: EXACT:R-SMAD(TGFB)
  Definition"A smad protein that mediates signal transduction through activation of transforming growth factor beta (TGF-beta) or activin pathways." [PMID:11532220] 
  PRO Categoryfamily 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 9                                        
         Sequence3                                                  Organism-Sequence 16                                        
         Modification28                                                  Organism-Modification 52                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500455
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000066 TGF-beta receptor-regulated smad protein, R-SMAD(TGFB)
Yes
gene


PR:000000364 smad2, SMAD2

organism-gene


PR:O70436 mothers against decapentaplegic homolog 2 (rat), rSMAD2

organism-gene


PR:P45896 dwarfin sma-3 (worm), SMAD2 (worm)

organism-gene


PR:Q15796 mothers against decapentaplegic homolog 2 (human), hSMAD2

organism-sequence


PR:000000470 smad2 sequence variant R133C (human), hSMAD2/var:R133C
Yes
organism-sequence


PR:000000471 smad2 sequence variant L440R (human), hSMAD2/var:L440R
Yes
organism-sequence


PR:000000472 smad2 sequence variant P445H (human), hSMAD2/var:P445H
Yes
organism-sequence


PR:000000473 smad2 sequence variant D450E (human), hSMAD2/var:D450E
Yes
organism-sequence


PR:000000474 smad2 sequence variant 5 (human), hSMAD2/var:5
Yes
organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human), hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human), hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human), hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human), hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human), hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human), hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human), hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human), hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human), hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000025960 smad2 isoform unphosphorylated 1 (human), hSMAD2/iso:[Long/Short]/UnPhos:1

organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human), hSMAD2/iso:Long/UnPhos:1

organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human), hSMAD2/iso:Short/UnPhos:1

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human), hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human), hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human), hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human), hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human), hSMAD2/InitMet-/UbiqLys+

organism-modification


PR:000050145 smad2 phosphorylated 1 (human), hSMAD2/Phos:1

organism-modification


PR:000060357 mothers against decapentaplegic homolog 2 sequence variant D300A, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300A/InitMet-/Phos:1

organism-modification


PR:000060522 mothers against decapentaplegic homolog 2 sequence variant S464L, initiator methionine removed form (human), hSMAD2/var:S464L/InitMet-

organism-modification


PR:000060657 mothers against decapentaplegic homolog 2 sequence variant D300V, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300V/InitMet-/Phos:1

organism-modification


PR:000060862 mothers against decapentaplegic homolog 2 sequence variant D300N, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:D300N/InitMet-/Phos:1

organism-modification


PR:000061944 mothers against decapentaplegic homolog 2 sequence variant A354T, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:A354T/InitMet-/Phos:1

organism-modification


PR:000062120 mothers against decapentaplegic homolog 2 sequence variant P305Q, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:P305Q/InitMet-/Phos:1

organism-modification


PR:000062419 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 2 (human), hSMAD2/InitMet-/Phos:2

organism-modification


PR:000063661 mothers against decapentaplegic homolog 2 sequence variant S464*, initiator methionine removed form (human), hSMAD2/var:S464*/InitMet-

organism-modification


PR:000063912 mothers against decapentaplegic homolog 2 sequence variant S467P, initiator methionine removed form (human), hSMAD2/var:S467P/InitMet-

organism-modification


PR:000064349 mothers against decapentaplegic homolog 2 sequence variant P305L, initiator methionine removed phosphorylated 1 (human), hSMAD2/var:P305L/InitMet-/Phos:1

organism-modification


PR:000064775 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated and ubiquitinated 1 (human), hSMAD2/InitMet-/PhosUbiq:1

organism-modification


PR:000065797 mothers against decapentaplegic homolog 2 methylated 1 (human), hSMAD2/Me:1

organism-modification


PR:000077056 mothers against decapentaplegic homolog 2 cysteinylated 1 (human), hSMAD2/Cyst:1

organism-gene


PR:Q62432 mothers against decapentaplegic homolog 2 (mouse), mSMAD2

organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse), mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse), mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse), mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse), mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse), mSMAD2/iso:Short/Phos:1
Yes
Yes
organism-gene


PR:Q9I9P9 mothers against decapentaplegic homolog 2 (zebrafish), z-SMAD2

sequence


PR:000000468 smad2 isoform Long, SMAD2/iso:Long

organism-sequence


PR:Q15796-1 mothers against decapentaplegic homolog 2 isoform Long (human), hSMAD2/iso:Long

organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human), hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human), hSMAD2/iso:Long/Phos:2
Yes
Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human), hSMAD2/iso:Long/Phos:3
Yes
Yes
organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human), hSMAD2/iso:Long/Phos:4
Yes
organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1
Yes
organism-modification


PR:000045371 smad2 isoform Long unphosphorylated 1 (human), hSMAD2/iso:Long/UnPhos:1
Yes
Yes
organism-sequence


PR:Q62432-1 mothers against decapentaplegic homolog 2 isoform Long (mouse), mSMAD2/iso:Long
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse), mSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse), mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form, SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1, SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form, SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1, SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse), mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000574 smad2 isoform Long phosphorylated form, SMAD2/iso:Long/PhosRes+

modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form, SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1, SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form, SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1, SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse), mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000650 smad2 isoform Long phosphorylated 1, SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human), hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse), mSMAD2/iso:Long/Phos:1
Yes
Yes
modification


PR:000000651 smad2 isoform Long phosphorylated 2, SMAD2/iso:Long/Phos:2

Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human), hSMAD2/iso:Long/Phos:2
Yes
Yes
modification


PR:000000652 smad2 isoform Long phosphorylated 3, SMAD2/iso:Long/Phos:3

Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human), hSMAD2/iso:Long/Phos:3
Yes
Yes
modification


PR:000000653 smad2 isoform Long phosphorylated 4, SMAD2/iso:Long/Phos:4

organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human), hSMAD2/iso:Long/Phos:4
Yes
modification


PR:000002570 smad2 isoform Long unmodified form, SMAD2/iso:Long/UnMod

Yes
modification


PR:000026718 smad2 isoform Long, initiator methionine removed form, SMAD2/iso:Long/InitMet-

sequence


PR:000000469 smad2 isoform Short, SMAD2/iso:Short

organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human), hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human), hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human), hSMAD2/iso:Short/UnPhos:1

organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse), mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse), mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form, SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1, SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000576 smad2 isoform Short phosphorylated form, SMAD2/iso:Short/PhosRes+

modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form, SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1, SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human), hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000656 smad2 isoform Short phosphorylated 1, SMAD2/iso:Short/Phos:1

Yes
organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human), hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse), mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000002571 smad2 isoform Short unmodified form, SMAD2/iso:Short/UnMod

modification


PR:000018296 smad2, initiator methionine removed form, SMAD2/InitMet-

modification


PR:000026718 smad2 isoform Long, initiator methionine removed form, SMAD2/iso:Long/InitMet-

organism-modification


PR:000049281 mothers against decapentaplegic homolog 2, initiator methionine removed form (human), hSMAD2/InitMet-

organism-modification


PR:000049282 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human), hSMAD2/InitMet-/Phos:1

organism-modification


PR:000049283 mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human), hSMAD2/InitMet-/Phos:5

organism-modification


PR:000049284 mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human), hSMAD2/InitMet-/UbiqLys+

modification


PR:000028327 smad2 unmodified form, SMAD2/UnMod

modification


PR:000002570 smad2 isoform Long unmodified form, SMAD2/iso:Long/UnMod

Yes
modification


PR:000002571 smad2 isoform Short unmodified form, SMAD2/iso:Short/UnMod

modification


PR:000025973 smad2 isoform unmodified form, SMAD2/iso:[Long/Short]/UnMod

Yes
modification


PR:000002570 smad2 isoform Long unmodified form, SMAD2/iso:Long/UnMod

modification


PR:000002571 smad2 isoform Short unmodified form, SMAD2/iso:Short/UnMod

modification


PR:000050146 smad2 phosphorylated 1, SMAD2/Phos:1

organism-modification


PR:000050145 smad2 phosphorylated 1 (human), hSMAD2/Phos:1

gene


PR:000000365 smad3, SMAD3

organism-gene


PR:P84022 mothers against decapentaplegic homolog 3 (human), hSMAD3

organism-sequence


PR:000062539 mothers against decapentaplegic homolog 3 sequence variant S425F (human), hSMAD3/var:S425F

organism-sequence


PR:000063486 mothers against decapentaplegic homolog 3 sequence variant S425C (human), hSMAD3/var:S425C

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human), hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:P84022-2 mothers against decapentaplegic homolog 3 isoform h2 (human), hSMAD3/iso:h2

organism-sequence


PR:P84022-3 mothers against decapentaplegic homolog 3 isoform h3 (human), hSMAD3/iso:h3

organism-sequence


PR:P84022-4 mothers against decapentaplegic homolog 3 isoform h4 (human), hSMAD3/iso:h4

organism-modification


PR:000049285 mothers against decapentaplegic homolog 3 phosphorylated 1 (human), hSMAD3/Phos:1

organism-modification


PR:000049286 mothers against decapentaplegic homolog 3 phosphorylated 2 (human), hSMAD3/Phos:2

organism-modification


PR:000049287 mothers against decapentaplegic homolog 3 ubiquitinated form (human), hSMAD3/UbiqLys+

organism-modification


PR:000064859 mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human), hSMAD3/PhosUbiq:1

organism-modification


PR:000060563 mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human), hSMAD3/var:R268H/Phos:1

organism-modification


PR:000061858 mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human), hSMAD3/ADPribPhos:1

organism-modification


PR:000063368 mothers against decapentaplegic homolog 3 phosphorylated 3 (human), hSMAD3/Phos:3

organism-modification


PR:000063580 mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human), hSMAD3/var:R268C/Phos:1

organism-modification


PR:000063639 mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human), hSMAD3/var:D258N/Phos:1

organism-modification


PR:000065228 mothers against decapentaplegic homolog 3 deaminated 1 (human), hSMAD3/Deam:1

organism-modification


PR:000065534 mothers against decapentaplegic homolog 3 methylated 1 (human), hSMAD3/Me:1

organism-modification


PR:000073148 mothers against decapentaplegic homolog 3 cysteinylated 1 (human), hSMAD3/Cyst:1

organism-modification


PR:000074741 mothers against decapentaplegic homolog 3 methylated 2 (human), hSMAD3/Me:2

organism-gene


PR:P84023 mothers against decapentaplegic homolog 3 (chicken), chick-SMAD3

organism-gene


PR:P84025 mothers against decapentaplegic homolog 3 (rat), rSMAD3

organism-gene


PR:Q8BUN5 mothers against decapentaplegic homolog 3 (mouse), mSMAD3

organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse), mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
sequence


PR:000000475 smad3 isoform 1, SMAD3/iso:1

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human), hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse), mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form, SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1, SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000578 smad3 isoform 1 phosphorylated form, SMAD3/iso:1/PhosRes+

modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form, SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1, SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human), hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000658 smad3 isoform 1 phosphorylated 1, SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human), hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse), mSMAD3/iso:1/Phos:1
Yes
modification


PR:000000659 smad3 isoform 1 phosphorylated 2, SMAD3/iso:1/Phos:2

organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse), mSMAD3/iso:1/Phos:2
Yes
modification


PR:000000660 smad3 isoform 1 phosphorylated 3, SMAD3/iso:1/Phos:3

organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse), mSMAD3/iso:1/Phos:3
Yes
modification


PR:000027744 TGF-beta receptor-regulated smad protein unmodified form, R-SMAD(TGFB)/UnMod

organism-modification


PR:000027745 TGF-beta receptor-regulated smad protein unmodified form (human), hR-SMAD(TGFB)/UnMod

modification


PR:000027746 TGF-beta receptor-regulated smad protein phosphorylated form, R-SMAD(TGFB)/PhosRes+

organism-modification


PR:000027747 TGF-beta receptor-regulated smad protein phosphorylated form (human), hR-SMAD(TGFB)/PhosRes+

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R-SMAD(TGFB) forms found in complexes   

R-SMAD(TGFB) Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:000025973 SMAD2/iso:[Long/Short]/UnMod PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000066 R-SMAD(TGFB)

"A smad protein that mediates signal transduction through activation of transforming growth factor beta (TGF-beta) or activin pathways." [PMID:11532220]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PIRSF:PIRSF500455
GO:0060395 SMAD protein signal transduction PIRSF:PIRSF500455
PR:000000470 hSMAD2/var:R133C
UniProtKB:Q15796, Arg-133, CHEBI:29950 | UniProtKB:Q15796-1, Arg-133, CHEBI:29950 | smad2 sequence variant 1 (human)
"A mothers against decapentaplegic homolog 2 (human) that has a Cys residue at the position equivalent to Arg-133 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950." [PMID:8752209, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8752209
associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000471 hSMAD2/var:L440R
UniProtKB:Q15796, Leu-440, CHEBI:29952 | UniProtKB:Q15796-1, Leu-440, CHEBI:29952 | smad2 sequence variant 2 (human)
"A mothers against decapentaplegic homolog 2 (human) that has an Arg residue at the position equivalent to Leu-440 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952." [PMID:8752209, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
PR:000000472 hSMAD2/var:P445H
UniProtKB:Q15796, Pro-445, CHEBI:29979 | UniProtKB:Q15796-1, Pro-445, CHEBI:29979 | smad2 sequence variant 3 (human)
"A mothers against decapentaplegic homolog 2 (human) that has a His residue at the position equivalent to Pro-445 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979." [PMID:8752209, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000473 hSMAD2/var:D450E
UniProtKB:Q15796, Asp-450, CHEBI:29972 | UniProtKB:Q15796-1, Asp-450, CHEBI:29972 | smad2 sequence variant 4 (human)
"A mothers against decapentaplegic homolog 2 (human) that has a Glu residue at the position equivalent to Asp-450 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972." [PMID:8752209, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8752209
enablesNOT GO:0003713 transcription coactivator activity PMID:8752209
PR:000000474 hSMAD2/var:5
UniProtKB:Q15796, 2-343, 359-467 | UniProtKB:Q15796-1, 2-343, 359-467
"A mothers against decapentaplegic homolog 2 (human) that has a fifteen-residue deletion at the position equivalent to region 344-358 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, 2-343, 359-467." [PMID:8673135, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:5672 large intestine cancer PMID:8673135
enablesNOT GO:0003713 transcription coactivator activity PMID:8673135
PR:000025934 hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936 hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
"A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025938 hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046
"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000025942 mSMAD2/iso:Long/Phos:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
enablesGO:0003713 transcription coactivator activity PMID:15282343
GO:0046332 SMAD binding PMID:11043574
located_inGO:0005634 nucleus PMID:11557747
PR:000025943 mSMAD2/iso:Short/Phos:1
UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046
"A smad2 isoform Short phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024
enablesGO:0003700 DNA-binding transcription factor activity PMID:15630024
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]		 acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036554 hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:15496141
enablesNOT GO:0003713 transcription coactivator activity PMID:15496141
PR:000036556 hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046
"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046
"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]		 enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]		 enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000045371 hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291
"A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enablesGO:0005515 protein binding PMID:8980228
located_inGO:0005737 cytoplasm PMID:15280432; PMID:17074053
GO:0005769 early endosome PMID:12356868
PR:P84022-1 hSMAD3/iso:1

"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
enablesGO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:O95405-1 PMID:12154125
located_inGO:0005737 cytoplasm PMID:17074053
PR:Q62432-1 mSMAD2/iso:Long

"A smad2 isoform Long that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747
located_inGO:0005737 cytoplasm PMID:14701940
PR:Q8BUN5-1 mSMAD3/iso:1

"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
enablesGO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125