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Protein Ontology report - smad4 isoform 1
PR:000000366 - http://purl.obolibrary.org/obo/PR_000000366
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000366   
  PRO namesmad4 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SMAD4/iso:1
  Definition"A smad4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13485-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000128
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000366 smad4 isoform 1, SMAD4/iso:1

Yes
organism-sequence


PR:P97471-1 mothers against decapentaplegic homolog 4 isoform 1 (mouse), mSMAD4/iso:1
Yes
Yes
organism-sequence


PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human), hSMAD4/iso:1
Yes
Yes
organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1
Yes
modification


PR:000000476 smad4 isoform 1 phosphorylated form, SMAD4/iso:1/PhosRes+

modification


PR:000000579 smad4 isoform 1 phosphorylated 1, SMAD4/iso:1/Phos:1

organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1
Yes
modification


PR:000002539 smad4 isoform 1 unmodified form, SMAD4/iso:1/UnMod

modification


PR:000025955 smad4 isoform 1 monoubiquitinated 1, SMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1

modification


PR:000025957 smad4 isoform 1 monoubiquitinated 2, SMAD4/iso:1/MonoUbiq:2

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2
Yes
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SMAD4/iso:1 forms found in complexes   

SMAD4/iso:1 Component
 Complexes
PR:000000366 SMAD4/iso:1 PR:000025967^P000025968^P000025969^P000025970^P000025971^P000025972
PR:P97471ZDASHZ1 mSMAD4/iso:1 PR:000025944^P000025945
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940^P000025946^P000025947^P000025951^P000025952
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148		 acts_upstream_of_or_withinGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enablesNOT GO:0046332 SMAD binding PMID:19135894
PR:000036483
hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enablesincreased GO:0003700 DNA-binding transcription factor activity relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_inGO:0005634 nucleus PMID:12801888
PR:P97471-1
mSMAD4/iso:1
 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805
GO:0030509 BMP signaling pathway PMID:16522160
enablesGO:0003700 DNA-binding transcription factor activity PMID:12943993; PMID:14633973; PMID:16522160; PMID:16556916
located_inGO:0005634 nucleus PMID:12543979; PMID:12943993; PMID:16522160
GO:0005667 transcription factor complex PMID:14633973; PMID:9288972; PMID:9702197
PR:Q13485-1
hSMAD4/iso:1
 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathway PMID:14633973
GO:0060395 SMAD protein signal transduction PMID:10980615; PMID:15350224; PMID:9346966
enablesGO:0003700 DNA-binding transcription factor activity PMID:10823886
GO:0003712 transcription coregulator activity PMID:10980615
located_inGO:0005634 nucleus PMID:10980615; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
GO:0005737 cytoplasm PMID:15280432