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Protein Ontology report - smad2 isoform Long phosphorylated form
PR:000000574 - http://purl.obolibrary.org/obo/PR_000000574
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000574   
  PRO namesmad2 isoform Long phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Long/PhosRes+
  Definition"A smad2 isoform Long that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000468 smad2 isoform Long
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification9                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000574 smad2 isoform Long phosphorylated form, SMAD2/iso:Long/PhosRes+

modification


PR:000000572 smad2 isoform Long acetylated and phosphorylated form, SMAD2/iso:Long/AcPhos+

modification


PR:000000649 smad2 isoform Long acetylated and phosphorylated 1, SMAD2/iso:Long/AcPhos:1

organism-modification


PR:000036554 smad2 isoform Long acetylated and phosphorylated 1 (human), hSMAD2/iso:Long/AcPhos:1
Yes
modification


PR:000000573 smad2 isoform Long phosphorylated and ubiquitinated form, SMAD2/iso:Long/PhosUbiq+

modification


PR:000000654 smad2 isoform Long phosphorylated and ubiquitinated 1, SMAD2/iso:Long/PhosUbiq:1

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
organism-modification


PR:000036482 smad2 isoform Long phosphorylated and ubiquitinated form (mouse), mSMAD2/iso:Long/PhosUbiq+

organism-modification


PR:000036555 smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse), mSMAD2/iso:Long/PhosUbiq:1
Yes
modification


PR:000000650 smad2 isoform Long phosphorylated 1, SMAD2/iso:Long/Phos:1

Yes
organism-modification


PR:000025934 smad2 isoform Long phosphorylated 1 (human), hSMAD2/iso:Long/Phos:1
Yes
Yes
organism-modification


PR:000025942 smad2 isoform Long phosphorylated 1 (mouse), mSMAD2/iso:Long/Phos:1
Yes
Yes
modification


PR:000000651 smad2 isoform Long phosphorylated 2, SMAD2/iso:Long/Phos:2

Yes
organism-modification


PR:000025935 smad2 isoform Long phosphorylated 2 (human), hSMAD2/iso:Long/Phos:2
Yes
Yes
modification


PR:000000652 smad2 isoform Long phosphorylated 3, SMAD2/iso:Long/Phos:3

Yes
organism-modification


PR:000025936 smad2 isoform Long phosphorylated 3 (human), hSMAD2/iso:Long/Phos:3
Yes
Yes
modification


PR:000000653 smad2 isoform Long phosphorylated 4, SMAD2/iso:Long/Phos:4

organism-modification


PR:000025937 smad2 isoform Long phosphorylated 4 (human), hSMAD2/iso:Long/Phos:4
Yes
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SMAD2/iso:Long/PhosRes+ forms found in complexes   

SMAD2/iso:Long/PhosRes+ Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025934 hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936 hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046
"A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025942 mSMAD2/iso:Long/Phos:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
enablesGO:0003713 transcription coactivator activity PMID:15282343
GO:0046332 SMAD binding PMID:11043574
located_inGO:0005634 nucleus PMID:11557747
PR:000036554 hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:15496141
enablesNOT GO:0003713 transcription coactivator activity PMID:15496141